In disuse atrophied skeletal muscle, the staircase response is virtually absent and light chain phosphorylation does not occur. The purpose of the present study was to determine if staircase could be restored in atrophied muscle with continued absence of myosin light chain phosphorylation, by reducing what appears to be an otherwise enhanced calcium release. Control (untreated) and sham-operate...

The Rockefeller University Press $30.00 J. Gen. Physiol. 2016 Vol. 147 No. 5 369–373 www.jgp.org/cgi/doi/10.1085/jgp.201611599 369 Release of Ca from intracellular stores is a ubiquitous mechanism that contributes to numerous physiological processes, including secretion, transcription, apoptosis, and contraction. In many cases, the rise in intracellular Ca is mediated by Ca release channels cal...