In Japan, the largest source of dioxin is solid waste incineration plants. Because workers employed at these plants handle fly ash and slag contaminated by dioxins, they can take dioxins into the body during work and their health may be adversely effected. This paper describes the dioxin exposure concentration, daily dioxin intake and blood dioxin level in workers employed at municipal incinera...

Many studies have shown an association between current daily levels of air pollution and daily mortality by respiratory and cardiovascular causes in the general population. However, the weak associations observed and the ecological nature of the exposure to air pollutants have created some doubts about plausibility of a causal relation. Specificity, which increases the plausibility of causal in...

Introduction: Today, WiFi radiofrequencies exposure is becoming almost unavoidable. Besides, aluminum widely used in daily life despite its involvement neurodegenerative diseases onset. /> <meta property=

OBJECTIVE This study examines effects of daily use of adult day service (ADS) programs by caregivers of individuals with dementia (IWD) on a salivary biomarker of stress reactivity, dehydroepiandrosterone-sulfate (DHEA-S), and whether these effects on DHEA-S are associated with daily variability in positive mood and depressive symptoms. METHODS We used a daily diary design of 8 consecutive da...

Antiviral pre-exposure prophylaxis (PrEP) through daily drug administration can protect healthy individuals from HIV-1 infection. While PrEP was recently approved by the FDA, the potential long-term consequences of PrEP implementation remain entirely unclear. The aim of this study is to predict the efficacy of different prophylactic strategies with the pro-drug tenofovir-disoproxil-fumarate (TD...

In children, omega-3 polyunsaturated fatty acids (PUFAs) may elicit a suite of health benefits including enhancement of cognitive development. Subsequently, dietary supplements containing omega-3 PUFAs have become increasingly popular. Often, the largest source of beneficial PUFAs in these supplements is fish oil, which may contain significant levels of contaminants such as polychlorinated biph...

OBJECTIVE To determine whether adolescent smoking behaviour is associated with their perceived exposure to teachers or other pupils smoking at school, after adjustment for exposure to smoking at home, in school, and best friends smoking. DESIGN Logistic regression analysis of cross sectional data from students in Denmark. SUBJECTS 1515 grade 9 students (mean age 15.8) from 90 classes in 48 ...

This study examines the interconnections among education--as a proxy for socioeconomic status--stress, and physical and mental healthy by specifying differential exposure and vulnerability models using data from The National Study of Daily Experiences (N = 1,031). These daily diary data allowed assessment of the social distribution of a qualitatively different type of stressor than has previous...

PURPOSE This phase I trial was undertaken to determine the maximum tolerated dose (MTD), dose-limiting toxicities (DLT), safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary antitumor activity of the novel smoothened inhibitor sonidegib (LDE225), a potent inhibitor of hedgehog signaling, in patients with advanced solid tumors. EXPERIMENTAL DESIGN Oral sonidegib was admini...

Tacrolimus a macrolide immunosuppressant that is routinely given in two equally divided doses every 12 h. However, the time-dependent pharmacokinetics of tacrolimus suggest that once daily morning administration of tacrolimus may produce appropriate drug exposure. The purpose of this pilot study was to compare the pharmacokinetics and safety of twice vs. once daily administration of tacrolimus ...