Abstract Background Acute liver failure (ALF) is associated with a high mortality rate, and there are still no effective treatments except transplantation artificial therapies. This study aimed to determine the effects, therapeutic window mechanisms of selonsertib, selective inhibitor ASK1, for ALF therapy. Results Lipopolysaccharide d -galactosamine (LPS/GalN) were used simulate ALF. We found ...

OBJECTIVE Vitamin D deficiency has been related to diabetes, hypertension, hyperlipidemia and peripheral vascular disease. In this study, we aimed to investigate the role of vitamin D status in non-alcoholic fatty liver disease. METHODS We included 211 consecutive subjects to examine the presence of non-alcoholic fatty liver disease. Of these subjects, 57 did not have non-alcoholic fatty live...

Shikonin, a naphthoquinone isolated from the root of medical herb Lithospermum erythrorhizon, has been reported to have anti-inflammatory effect. However, there is no related research for the treatment of shikonin on hepaic injury. The purpose of this study was to investigate the effects of shikonin on D-Galactosamine and Lipopolysaccharide-induced hepatic injury in mice. Male BALB/c mice were ...

introduction: to determine an indicator for triclabendazole (tcbz) efficacy, alanine aminotransferase (alt) activity in fasciola hepatica (iranian isolate) parasite in presence and absence of tcbz was evaluated by an in vitro cultivation method. also, alt enzyme activity between none and parasitized-infected sheep liver tissues was assessed. method:  the sheep livers were collected and transfer...

Penicillin acylase of Escherichia coli catalyses the hydrolysis and synthesis of beta-lactam antibiotics. To study the role of hydrophobic residues in these reactions, we have mutated three active-site phenylalanines. Mutation of alphaF146, betaF24 and betaF57 to Tyr, Trp, Ala or Leu yielded mutants that were still capable of hydrolysing the chromogenic substrate 2-nitro-5-[(phenylacetyl)amino]...

aim: the healthy ranges for serum alanine aminotransferase (alt) levels are less well studied. the aim of this study was to define the upper limit of normal (uln) for serum alt levels, and to assess factors associated with serum alt activity in apparently healthy blood donors. methods: a total of 1939 blood donors were included. alt measurements were performed for all cases using the same labor...

Ascorbic Acid and Chronic Alcohol Consumption in the Guinea Pig. SUSICK, R. L., JR., ABRAM& G. D., ZURAWSKI, C. A., AND ZANNONI, V. G. (1986). Toxicol. Appl. Pharmacol. 84,329-335. Protection against the toxic effects of chronic alcohol consumption was observed in male guinea pigs maintained on a high-ascorbic-acid diet (vitamin C-deficient chow plus 2.0 mg ascorbic acid/ml drinking water) as c...

The protective effect of a fermented substance from Saccharomyces cerevisiae (FSSC) on liver injury caused by acetaminophen (AAP) was studied in mice. Mice were pretreated with FSSC (0.5-2.0 g/kg, p.o.) for 4 d, and on the fourth day, the mice received an overdose of AAP (500 mg/kg, i.p.). Subsequently, they were sacrificed at 7 h, and blood was drawn from the abdominal vein and liver samples w...