A patient with severe lupus nephritis developed thrombocytopenia during treatment with high-dose steroids. In addition to viral- or disease-induced cytopenia, the pathology was believed to arise from diverse contributing factors, such as thrombotic microangiopathy and heparin-related thrombocytopenia (HIT). By combining plasma exchange therapy and intravenous cyclophosphamide, we successfully c...

T HE HUMAN immunodeficiency virus (HIV) has been identified as the causal agent for the acquired immunodeficiency syndrome (AIDS). Infection with this virus has been associated with a broad range of clinical outcomes, particularly evident in the hematopoietic system. Impaired hematopoiesis, immune-mediated cytopenia, and altered coagulation parameters have been described following HIV infection...

リンパ球系腫瘍ではしばしば自己免疫性血球減少（AIC）を合併する．しかし，どのような特徴をもつ症例で合併しやすいかは明らかでない．当院で診断した低悪性度B細胞腫瘍（LGBCM）155例を対象とし，immunoglobulin（Ig）の増加と，AICの合併頻度を後方視的に検討した．6例がAICを合併し，そのうち4例でIgが増加していた．4例中3例がmonoclonal（Mono）IgGを伴い，その3例中1例はpolyclonal（Poly）なIgM増加を伴った．その他の1例ではPoly-IgM増加のみを認めた．Mono-IgGを伴う症例では，AICの合併が多かった（p＝0.018）．一方，Poly-Ig増加や，Mono-IgMおよびMono-IgAを伴う症例では，AIC合併の増加はなかった．Mono-IgGを伴うLGBCMでは，AIC合併に留意して診療を行う必要があると考えられた．

BackgroundClonal hematopoiesis of indeterminate potential (CHIP) and clonal cytopenia undetermined significance (CCUS) are defined by somatic mutations in genes associated with myeloid neoplasms (MN) at a variant allele fraction (VAF) 0.02 or greater the absence presence cytopenia, respectively. CHIP/CCUS is highly prevalent adults, defining predictors MN risk would aid clinical management rese...

ABSTRACT Three patients were diagnosed at our facility with therapy-related acute myeloid leukemia (t-AML) but had differing etiologies. Patient A was a 30-year-old male history of lymphoblastic in remission. The patient admitted to the hospital early 2019 for pain control and concurrent pancytopenia. bone marrow biopsy performed because concern relapsed disease. showed 96.6% blasts 95...