نتایج جستجو برای: cystatin c

تعداد نتایج: 1057234  

Journal: :The Journal of clinical investigation 1999
G P Shi G K Sukhova A Grubb A Ducharme L H Rhode R T Lee P M Ridker P Libby H A Chapman

The pathogenesis of atherosclerosis and abdominal aortic aneurysm involves breakdown of the elastic laminae. Elastolytic cysteine proteases, including cathepsins S and K, are overexpressed at sites of arterial elastin damage, but whether endogenous local inhibitors counterbalance these proteases is unknown. We show here that, whereas cystatin C is normally expressed in vascular wall smooth musc...

Journal: :Clinical chemistry 2005
Wolfgang Koenig Dorothee Twardella Hermann Brenner Dietrich Rothenbacher

BACKGROUND Renal impairment (RI) is associated with worse prognosis. Recently, cystatin C has been shown to represent a potentially superior marker of the glomerular filtration rate compared with creatinine clearance (CrCl). We evaluated the impact of cystatin C and other markers of RI on prognosis in a large cohort of patients with coronary heart disease (CHD). METHODS Cystatin C, creatinine...

Journal: :pharmaceutical and biomedical research 0
reza golam mohebbi graduate of veterinary medicine, islamic azad university, urmia branch, urmia, iran kaveh azimzadeh department of clinical sciences, veterinary faculty, urmia branch, islamic azad university, urmia, iran amir amniattalab department of pathobiology, veterinary faculty, urmia branch, islamic azad university, urmia, iran

this study aimed to assess whether the triethylenetetramine (teta) is impressed the plasma level of homocysteine (hcy), total sialic acid (tsa) and cardiac troponin i (ctni) as cardiovascular diseases risk factors, cystatin c (cys c) and glucose along with histopathologic changes in alloxan induced diabetes mellitus in rabbit. twenty number new zealand white rabbits were assigned for this study...

2014
Kwang-Sook Woo Jae-Lim Choi Bo-Ram Kim Ji-Eun Kim Jin-Yeong Han

BACKGROUND Accurate renal function measurements are important in the diagnosis and treatment of kidney diseases. In contrast to creatinine, the production of serum cystatin C has been extensively reported to be unaffected by body muscle mass, age, gender, and nutritional status. METHODS Our study included 37 samples from diabetic chronic kidney disease (CKD) patients for whom serum creatinine...

Journal: :Journal of cardiac failure 2011
Francisco Javier Carrasco-Sánchez Luis Galisteo-Almeda Inmaculada Páez-Rubio Francisco Javier Martínez-Marcos Crescencio Camacho-Vázquez Carlos Ruiz-Frutos Emilio Pujol-De La Llave

BACKGROUND Cystatin C has emerged as a new biomarker of renal function that has been found to predict adverse cardiovascular outcomes, especially heart failure (HF). Evidence of the usefulness of cystatin C in patients with heart failure with preserved ejection fraction (HFPEF) remains sparse. It is hypothesized that serum cystatin C levels in HFPEF has prognostic value. METHODS AND RESULTS C...

2003
Alona Pavlova

Pavlova, A., 2003. Mechanism of action of mammalian cystatins. Studies of inhibition of cysteine endoand exopeptidases by cystatins A and C. Doctor's dissertation. ISSN 1401-6257, ISBN 91-576-6379-3. Mammalian cystatins are tight-binding, reversible inhibitors of potentially destructive cysteine proteases, both endogenous and exogenous. The N-terminal region residues, Ile2 and especially Pro3, ...

2017
Tomomi Murai Noriko Takebe Kan Nagasawa Yusuke Todate Riyuki Nakagawa Rieko Nakano Mari Hangai Yutaka Hasegawa Yoshihiko Takahashi Kunihiro Yoshioka Yasushi Ishigaki

OBJECTIVE Accumulation of epicardial adipose tissue (EAT) is considered to be a cardiovascular risk factor independent from visceral adiposity, obesity, hypertension and diabetes. We explored the parameters related to EAT accumulation, aiming to clarify the novel pathophysiological roles of EAT in subjects with type 2 diabetes (T2DM). METHODS We examined the laboratory values, including cysta...

Journal: :Annales de biologie clinique 2013
Sonia Triki Ons Fekih Ilhem Hellara Fadoua Neffati Wahiba Douki Khaldoun Ben Hamda Faouzi Maatouk Mohamed Fadhel Najjar

Serum cystatin C concentration was recently reported as a marker of cardiovascular disease (CVD). In the present study, we evaluated the association between the increase of serum cystatin C levels and the risk of CVD in type 2 diabetes. 42 patients with type 2 diabetes were included in the present study; 27 of them have CVD. The control group consisted of 30 healthy adults. Cystatin C, creatini...

Journal: :Clinical chemistry 2001
Aras O M Y Tsai N Q Hanson R Bailey G Rao D B Hunninghake

BACKGROUND An increased prevalence of hyperhomocysteinemia with an increased incidence of cardiovascular disease events has been reported among stable renal transplant recipients (RTRs). Preliminary studies in a small number of these individuals have shown that serum creatinine and cystatin C, both markers of kidney function and glomerular filtration rate, are independent determinants of fastin...

2014
Arndt-Holger Kiessling Juliane Dietz Christian Reyher Ulrich A Stock Andres Beiras-Fernandez Anton Moritz

OBJECTIVE Acute kidney injury (AKI) after cardiac surgery procedures is associated with poor patient outcomes. Cystatin C as a marker for renal failure has been shown to be of prognostic value; however, a wide range of its predictive accuracy has been reported. The aim of the study was to evaluate whether the measurement of pre- and postoperative serum cystatin C improves the prediction of AKI....

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