The single tryptophan residue Trp-104 of chicken cystatin was modified with a 2-hydroxy-5-nitrobenzyl group. The change of the absorption spectrum of this group on binding of the modified cystatin to papain indicated a decreased environmental polarity of the probe. The modified inhibitor had about a 10(5)-fold lower affinity for papain than had intact cystatin, this being due to a higher dissoc...

Shrunken Pore Syndrome was recently suggested for the pathophysiologic state in patients characterized by an estimation of their glomerular filtration rate (GFR) based upon cystatin  C, which is lower or equal to 60% of their estimated GFR based upon creatinine, i.e. when eGFR cystatin  C ≤ 60% of eGFR creatinine. Not only the cystatin C level, but also the levels of other low molecular mass pr...

PURPOSE The purpose of this study was to evaluate the accuracy of plasma cystatin C in acute impairment in renal function; plasma cystatin C was compared to plasma creatinine in two hundred patients undergoing elective CABG surgery. METHODS We performed a prospective clinical study of two hundred patients undergoing coronary bypass surgery. Plasma creatinine and cystatin C were measured preop...

PURPOSE To evaluate plasma cystatin level as a covariate to predict topotecan pharmacokinetics. Cystatin C, a member of the cystatin superfamily of cysteine proteinase inhibitors, has been recently proposed as an alternative endogenous marker of glomerular filtration. Renal function is known as a key factor of topotecan clearance. EXPERIMENTAL DESIGN Data were obtained from 59 patients who un...

OBJECTIVES To determine the association between cognition and levels of cystatin C in persons with chronic kidney disease (CKD). DESIGN Prospective observational study. SETTING Chronic Renal Insufficiency Cohort Cognitive Study. PARTICIPANTS Individuals with a baseline cognitive assessment completed at the same visit as serum cystatin C measurement (N = 821; mean age 64.9, 50.6% male, 48....

BACKGROUND Limited data is available on kidney function in HIV-infected children in sub-Saharan Africa. In addition, malnutrition in these children further reduces the utility of diagnostic methods such as creatinine-based estimates of glomerular filtration rate. We determined the serum cystatin C level and estimated glomerular filtration rate of 60 antiretroviral-naïve, HIV-infected children a...

BACKGROUND Cystatin C has been known to be associated not only with early renal impairment but also with the incidence of diabetic conditions (prediabetes plus diabetes). However, it is not clear whether cystatin C levels are associated with the prevalence of diabetic conditions in Asian populations. We evaluated this association using glycosylated hemoglobin (HbA1c) levels as the definition of...

BACKGROUND/AIMS Height-adjusted total kidney volume (htTKV) is the best marker of disease progression in early autosomal dominant polycystic kidney disease (ADPKD) when renal function still remains normal. The usefulness of cystatin-C as a biomarker to assess renal function according to renal volume has not been studied in ADPKD patients. METHODS Observational and cross-sectional study of 62 ...

chronic inflammation is associated with the development of various diseases such as atherosclerosis and diabetes. the aim of this study was to investigate the effect of 8 weeks of resistance training on changes of c reactive protein (crp) and cystatin c in male volleyball players. for this purpose, 20 volleyball players voluntarily participated in the study and were divided randomly into progre...

The work by Dr. Francisco Ortuño-Andériz et al.,1 is an important contribution to delineate the use of cystatin C in intensive care. Cystatin C was described as a marker of glomerular filtration rate, GFR, about 30 years ago,2,3 but it was not until 1994, when it was stated to be a more accurate marker for GFR than creatinine,4 that substantial efforts were initiated to define its role as a mar...