This study was undertaken to examine the response to ergonovine, an agent used to provoke spastic constriction of large epicardial coronary arteries, to elucidate the responsible underlying mechanism, and to determine the impact of endogenous hyperlipidemia on contractile properties of isolated vessels from different beds. The isolated arteries from both control and Watanabe hereditary hyperlip...

Sensitive, accurate and precise methods for the qauantitative determination of Seven drugs viz., Cyclobenzaprine HCl (CYC), Cyproheptadine HCl (CYP), Dobutamine HCl (DOB), Moxifloxacin HCl (MOX), Pamiprioxole HCl (PAM), Sumatriptan succinate (SUM) and Trimetazadine 2HCl(TRI) haave been developed . The methods are based on the charge transfer interqction of iodine with drugs which resulted in th...

The clinical features and risk of hepatotoxicity of 'Sleep-Qik' (valerian dry extract 75 mg, hyoscine hydrobromide 0.25 mg, cyproheptadine hydrochloride 2 mg) were determined in 23 patients treated in our hospital between 1988 and 1991. The main clinical problems were central nervous system depression and anticholinergic poisoning. There was no clinical evidence of acute hepatitis in the 23 pat...

The effectiveness of five different serotonin antagonists in the prevention of migraine was compared in 290 patients followed for periods of up to three years. Methysergide 3-6 mg. daily was most effective, with 20% of treated patients becoming headache-free and a further 44% remaining more than "half improved." The corresponding figures for BC105 were 10% and 40%, respectively.The results with...

Rocha e Silva and Rosenthal (1) have reported that the exudates from burnt rat skin contain histamine, bradykinin, adenosine derivatives and possibly serotonin and other as yet unidentified pharmacologically active and toxic substances. Hodson (2) has reported the peripheral antiserotonin activity of B.W. 501 C 67 (α-anilino-N-2-m-chlorophenoxypropyl acetamidine hydrochloride monohydrate)...

Mitragynine is a major alkaloidal constituent of young leaves of Mitragyna speciosa Korth, that is known to exhibit narcotic-like activity. In this study, we investigated the roles of central monoaminergic systems in the antinociceptive action of mitragynine by means of the tail-pinch and hot-plate tests in mice. Mitragynine (1.0-10 micrograms) injected i.c.v. exerted a dose-dependent antinocic...

Abstract This study establishes a method for rapid detection of clonidine and cyproheptadine in foods animal origin. In order to obtain the best method, capillary zone electrophoresis (CZE), large volume sample stacking (LVSS), sweeping-micellar electrokinetic chromatography (sweeping-MEKC) were used respectively. The limits (LODs) by LVSS-CZE 0.028 ?g mL ?1 0.034 , those sweeping-MEKC 0.023 0....

Elevated levels of serotonin (5-hydroxytryptamine, 5-HT) are observed in the serum of asthmatics. Herein, we demonstrate that 5-HT functions independently as an eosinophil chemoattractant that acts additively with eotaxin. 5-HT2A receptor antagonists (including MDL-100907 and cyproheptadine (CYP)) were found to inhibit 5-HT-induced, but not eotaxin-induced migration. Intravital microscopy studi...

While the role of 5-hydroxytryptamine (5-HT, serotonin) in the nociceptive processing has been widely investigated in the central nervous system, information regarding its role in peripheral tissues is still lacking. Noteworthy, 5-HT induces phenotypic changes of nociceptors and peripheral injection induces pain in humans and nociceptive response in rodents. However, local receptors involved in...