نتایج جستجو برای: cyclic nucleotides
تعداد نتایج: 130320 فیلتر نتایج به سال:
The 4-chlorophenylthio analogue of cyclic AMP evoked profound and long-lasting changes in cytosolic [Ca2+] ([Ca2+]i) in pituitary-derived GH3 cells. However, vasoactive intestinal peptide (VIP), a hormone considered to act via cyclic AMP, was ineffective in modulating [Ca2+]i. The ability of VIP to modulate [Ca2+]i was enhanced by treatments that increased intracellular cyclic AMP. Much greater...
The cyclic nucleotide-regulated ion channels are a heterogeneous superfamily of different ion channels that share common membrane topology and pore structure and display a cyclic nucleotide-binding domain in their C-terminal region. Members of this superfamily include cyclic nucleotide-gated (CNG) cation channels, hyperpolarizationactivated cyclic nucleotide-gated (HCN) cation channels and also...
BACKGROUND Impairment of platelet response to antiaggregatory agents is seen in individuals with central obesity and may play a role in the increased cardiovascular risk associated with obesity. In this study we evaluated whether this impairment involves the antiaggregatory pathways regulated by cAMP and cGMP. METHODS We obtained platelet-rich plasma from 12 obese individuals and 12 controls....
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