DFT calculations on the full catalytic cycle for manganese catalysed enantioselective hydrogenation of a selection ketones have been carried out at PBE0-D3PCM//RI-BP86PCM level. Mn complexes an enantiomerically pure chiral P,N,N ligand found to be most reactive when adopting facial coordination mode. The use new with ortho-substituted dimethylamino-pyridine motif has calculated completely trans...

Asymmetric catalytic transfer hydrogenation using 2-propanol as a hydrogen source offers an attractive route for reducing simple unfunctionalized ketones to chiral alcohols.1 The reaction uses inexpensive reagents and is usually easy to perform. Notable among the recently developed efficient transition-metal-based chiral reduction catalysts2 is the Ru(II)-TsDPEN (TsDPEN ) N-(p-tolylsulfonyl)-1,...

The scope and limitation of the transformation of ketones to enones by selenenylation followed by selenoxide elimination have been examined. Several procedures for the preparation of a-phenylseleno ketones have been developed. The most useful are direct selenenylation of ketone enolates using PhSeBr and the reaction of enol acetates with electrophilic selenium species such as benzeneselenenyl t...

An ytterbium catalyzed formal [3+3] cycloaddition of cyclic enamines and ?,?-unsaturated ketones is reported. The reaction proceeds with a ‘head to tail’ regioselectivity through conjugate addition the enamine moiety followed by an amine-carbonyl condensation. In use chiral provided high degree stereoselectivity, driven possible balance between steric ?-stacking effects. resulting bicyclic 1,4-...

Furanaphthoquinones are well known in medicinal chemistry for exhibiting relevant structural heterogeneity and bioactivities. In this work, it was synthesized a series of furanaphthoquinones through tandem reaction between lawsone (8) cyclic ketones the presence morpholine. This strategy provides an efficient general method synthesizing with activity against epimastigote form Trypanosoma cruzi ...

Catalytic asymmetric Corey-Chaykovsky epoxidation of various ketones with dimethyloxosulfonium methylide using a heterobimetallic La-Li(3)-BINOL complex (LLB) is described. The reaction proceeded smoothly at room temperature in the presence of achiral phosphine oxide additives, and 2,2-disubstituted terminal epoxides were obtained in high enantioselectivity (97%-91% ee) and yield ( > 99%-88%) f...