نتایج جستجو برای: cyanex 302

تعداد نتایج: 6187  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2000
M Sahin-Tóth A Karlin H R Kaback

We studied the effect of pH on ligand binding in wild-type lactose permease or mutants in the four residues-Glu-269, Arg-302, His-322, and Glu-325-that are the key participants in H(+) translocation and coupling between sugar and H(+) translocation. Although wild-type permease or mutants in Glu-325 and Arg-302 exhibit marked decreases in affinity at alkaline pH, mutants in either His-322 or Glu...

Journal: :Cancer research 1993
F E Ahmed R B Setlow

Fluence response relationships for the induction of DNA damage in the skin of UV-irradiated Xiphophorus fish were obtained by quantitative gel electrophoresis of unlabeled DNA following extraction and treatment with an enzyme preparation that makes single strand breaks next to cyclobutane pyrimidine dimers. A buffer containing 7 M urea minimized the degradation of DNA during extraction and gave...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه تربیت مدرس - دانشکده علوم پایه 1390

سرطان مثانه یکی از شایع ترین سرطان ها در دنیا می باشد. در ایران نیز این سرطان سومین سرطان شایع در بین مردان و دهمین سرطان شایع بین زنان می باشد: در نتیجه انجام تحقیقات در مورد این سرطان و یافتن مارکرهایی برای تشخیص زود هنگام سرطان و یا حتی برای درمان آن لازم و ضروری به نظر می رسد. microrna ها (mirna ها ) rna های کوچک غیر کد کننده ای هستند که با خاموش کردن بیان ژن ها در سطح پس از رونویسی نقش بس...

Journal: :Journal of cell science 2012
Noel Faherty Simon P Curran Helen O'Donovan Finian Martin Catherine Godson Derek P Brazil John K Crean

Signalling interplay between transforming growth factor-β (TGFβ) and CCN2 [also called connective tissue growth factor (CTGF)] plays a crucial role in the progression of diabetic nephropathy and has been implicated in cellular differentiation. To investigate the potential role of microRNAs (miRNAs) in the mediation of this signalling network, we performed miRNA screening in mesangial cells trea...

Journal: :The Biochemical journal 1992
E E Blatter D P Abriola R Pietruszko

4-trans-(NN-Dimethylamino)cinnamaldehyde (an aldehyde, DACA) and 4-trans-(NN-dimethylamino)cinnamoylimidazole (an amide, DACI) have been shown to be substrates for human aldehyde dehydrogenase (EC 1.2.1.3) which form chromophoric covalent intermediates. The spectra of covalent intermediates from both the cytoplasmic (E1) and mitochondrial (E2) isoenzymes derived from DACA and DACI were compared...

2009
Charles W. Whitfield

www.sciencemag.org (this information is current as of July 7, 2009 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/302/5643/296 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/302/5643/296/DC1 can be found at...

2016
Ines Lohse Joanna Rasowski Pinjiang Cao Melania Pintilie Trevor Do Ming-Sound Tsao Richard P. Hill David W. Hedley

Previous reports have suggested that the hypoxic microenvironment provides a niche that supports tumor stem cells, and that this might explain clinical observations linking hypoxia to metastasis. To test this, we examined the effects of a hypoxia-activated prodrug, TH-302, on the tumor-initiating cell (TIC) frequency of patient-derived pancreatic xenografts (PDX).The frequencies of TIC, measure...

2005
D. M. Smith W. A. Heindl C. B. Markwardt J. H. Swank

XTE J1739–302 is a transient X-ray source with unusually short outbursts, lasting on the order of hours. Here we give a summary of X-ray observations we have made of this object in outburst with the Rossi X-ray Timing Explorer (RXTE) and at a low level of activity with the Chandra X-ray Observatory, as well as observations made by other groups. Visible and infrared spectroscopy of the mass dono...

2006
Ronald Jansen

www.sciencemag.org (this information is current as of November 28, 2006 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/302/5644/449 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/302/5644/449/DC1 can be fou...

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