In this study, some physiological indexes of leaves in transgenic sweetpotato (Ipomoea batatas L. cv. Yulmi), which harbors two genes CuZn superoxide dismutase (CuZnSOD) and ascorbate peroxidase (APX) genes, with the stress-inducible SWPA2 promoter were evaluated under different concentrations of NaCl treatment. The results showed that physiological indexes were no remarkable differences withou...

AIM The anti-oxidant enzyme copper/zinc superoxide dismutase (CuZnSOD) metabolizes superoxide anion (O(2)(-)) in vascular cells. However, the role of CuZnSOD in vascular injury remains poorly understood. METHODS Using CuZnSOD-deficient (CuZnSOD(-/-)) mice and wild-type (WT) mice, we investigated morphometric changes and the role of O(2)(-) in vascular remodeling after femoral artery injury in...

BACKGROUND AND PURPOSE To clarify the effect of superoxide dismutase (SOD) on vasospasm after subarachnoid hemorrhage (SAH), we investigated sequential changes in arterial diameter after SAH in transgenic mice overexpressing CuZn-SOD (SOD-1). METHODS SOD-transgenic mice and nontransgenic littermates (35 to 40 g) were subjected to SAH produced by endovascular perforation of left anterior cereb...

conclusions the administration of 75 mg/kg/day cinnamon significantly increased the sperm population, motility and viability, which supports the theory that in mammalians, cinnamon has a beneficial effect on spermatogenesis. results sperm quality parameters, total serum testosterone, sod, cat, and gpx levels were significantly increased in the cinnamon group in comparison to controls (p < 0.05)...

The goal of the present study was to test the hypothesis that the CuZn isoform of superoxide dismutase (CuZnSOD) protects against angiotensin II (Ang II)-induced endothelial dysfunction. Vascular responses of carotid arteries from control, CuZnSOD-deficient (CuZnSOD(+/-)), and CuZnSOD transgenic mice were examined in vitro after overnight incubation with either vehicle or Ang II (1 or 10 nmol/L...

In recent years, genetically altered mice, either overexpressing or deficient in specific gene products, have come to play a vital role in experimental studies designed to probe the molecular pathophysiology of ischemic brain injury. More than 100 such studies have been reported to date, and notable successes have been achieved in elucidating the roles of the neuronal,1,2 endothelial,3 and indu...

Mitochondrial DNA (mtDNA) deletion mutations are proposed contributors to aging-related muscle fiber loss and atrophy, but evidence of a causal role for these mutations in muscle aging is lacking. Elucidating the etiology of in vivo mtDNA deletion mutations will help to better understand and test the possible roles of these mutations in aging. The implication of mtDNA mutations in aging is base...

Reactive oxygen species have been implicated as a cause of cancer and aging in mammals. Mice deficient for the antioxidant enzyme CuZn-superoxide dismutase (Sod1) have a decreased life span and an elevated incidence of liver cancer. To test the hypothesis that the cancer-prone phenotype in such mice is due to accelerated spontaneous mutation accumulation, we crossed these mutants with mice harb...