Integration of human papillomavirus (HPV) DNA into the host cell genome is a frequent event in cervical carcinogenesis, even though this phenomenon does not seem to be mandatory for cervical cancer development. Our objective was to describe the load and physical state of HPV type 16 (HPV16) DNA in a series of cervical samples representative of the natural history of cervical cancer. We used a c...

OBJECTIVES To determine the associations between serum cancer antigen 15-3 levels and prognostic factors in patients with endometrial carcinomas. Additionally, we investigated the clinical utility of serum cancer antigen 15-3 levels in the selection of low-risk patients with endometrioid type, tumor size less than 2 cm, myometrial invasion ≤50%, and histological grade 1-2. Methods: Ninety-six p...

background: waist circumference (wc) is an accurate and simple measure of abdominal obesity as compared to waist–hip ratio (whr). the aim of this study was to determine the correlation between body mass index (bmi) with wc and whr and suggest cutoff points for wc among rural malaysian adults. methods: a cross‑sectional study was conducted among 669 respondents from three villages in tanjung kar...

OBJECTIVE To evaluate the feasibility of DNA image cytometry (DNA-ICM) as a primary screening method for esophageal squamous cell cancer (ESCC). METHODS A total of 5,382 local residents aged 40-69 years from three high-risk areas in China (Linzhou in Henan province, Feicheng in Shandong province and Cixian in Hebei province) from 2008 to 2011 were recruited in this population-based screening ...

Purpose Even though 95% of children with neurodevelopmental disorders, including autism spectrum disorder (ASD), live in low- and middle-income countries, there is a dearth studies from these the Republic Georgia. Several ASD screening tools are available, but few validated for use Georgian or other smaller countries. This study aims to adapt validate questionnaire (ASSQ) Design/methodology/app...

Background: Fibroscan (transient elastography) is a relatively new method of measuring liver stiffness and noninvasive fibrosis marker. The could be used as predictors oesophageal varices in cirrhotic patients because portal hypertension related to fibrosis. Objectives: This study aimed evaluate the diagnostic accuracy transient elastography for presence grade (EV) with cirrhosis. Methods: cros...