Introduction: Signet ring cell carcinoma is a rare form of highly malignant adenocarcinoma, with the prevalence rate < 1%. The most common site primary tumor stomach, and secondary sites are breast, gall bladder, urinary pancreas. Moreover, metastasis signet carcinomas lung liver. Skin extremely rare, 0.3%. usually diagnosed during late stages disease; hence, tumors spread more aggressively ...

BACKGROUND ABO blood groups have been suggested to contribute to the development of certain tumors; however, the associations between ABO blood groups and the incidence and metastases of cutaneous malignant melanomas have not been fully evaluated in Chinese populations. Thus, we investigated these associations with a case-controlled study in northeast of China. METHODS A total of 482 patients...

CUTANEOUS MALIGNANT MELANOMA OF THE BREAST CAN BE DIVIDED INTO TWO CATEGORIES: primary and metastatic lesions. Cutaneous malignant melanoma of the breast is a rare tumor, accounting for less than 5% of all malignant melanomas. Clinical features and diagnostic methods of primary cutaneous malignant melanoma of the breast are similar to those arising from other cutaneous areas. Treatment of choic...

BACKGROUND Cutaneous smooth muscle tumors are rare and sometimes the differential diagnosis between leiomyoma and leiomyo-sarcoma is difficult and based in very subtle criteria. We therefore tried to investigate the use of p53 in such a conundrum. This marker has rarely been reported in cutaneous leiomyomas and even in more rare occasions, in cutaneous leiomyomas. MATERIAL AND METHODS We stud...

BackgroundCurrent staging systems for cutaneous squamous cell carcinoma (cSCC) have limited positive predictive value identifying patients who will experience metastasis.ObjectiveTo develop and validate a gene expression profile (GEP) test predicting risk metastasis in localized, high-risk cSCC with the goal of improving risk-directed patient management.MethodsArchival formalin-fixed paraffin-e...

Choriocarcinoma is one of the malignant tumors of trophoblastic cells characterized by the secretion of human chorionic gonadotrophin (hCG) (1-3). Cutaneous metastasis is a rare presentation of choriocarcinoma but a poor prognostic sign because it is associated only with widespread disease (3-5). A 52-yr-old female complaining of dyspnea for 2 months, presented with fingertip sized erythematous...