Components for off-road bicycles including handlebars continue to be recalled with regularity because of problems with structural failure as a result of high cycle fatigue in the off-road environment. The objectives of this study were to 1) devise a method for determining the point on the handlebar cross section that experiences the maximum cumulative damage when the handlebar is subjected to l...

INTRODUCTION Osteopontin (OPN) has been implicated as a mediator of Th17 regulation via type I interferon (IFN) receptor signaling and in macrophage activity at sites of tissue repair. This study assessed whether increased circulating plasma OPN (cOPN) precedes development of organ damage in pediatric systemic lupus erythematosus (pSLE) and compared it to circulating plasma neutrophil gelatinas...

We investigate the time-scale invariant changes in electromagnetic and mechanical energy releases prior to a rock failure or a large earthquake. The energy release processes are caused by damage evolutions such as crack propagation, motion of charged dislocation, area-enlargement of sheared asperities and repetitive creep-rate changes. Damage mechanics can be used to represent the time-scale in...

A new mixture toxicity model was developed to predict the time-dependent toxicity of a mixture with toxicokinetic interactions directed specifically toward addressing biotransformation. The Damage Assessment Model (DAM), a toxicokinetic-toxicodynamic model that describes and predicts the time-dependent toxicity of a single compound, was extended to a multicomponent model for mixture toxicity. T...

The potential effect of electromagnetic fields (EMFs) emitted from video display terminals (VDTs) to elicit biological response is a major concern for the public. The software professionals are subjected to cumulative EMFs in their occupational environments. This study was undertaken to evaluate DNA damage and incidences of micronuclei in such professionals. To the best of our knowledge, the pr...

Heat damage to seed can occur as a result of the cumulative effects of respiration and fungal heating, and by the accumulation and retention of radiant heat within the seed mass following harvest both situations being collectively referred to as ‘field heating’. Another type of heating damage occurs in heated air drying systems. Excessive drying air temperature can have deleterious effects on s...

Fatigue life of Ti alloys is decreased by tensile stress dwell even at room temperature, which called Cold Dwell (CDF). CDF similar to creep-fatigue some metals (stainless steel, Ni-base alloy, and so on) in the point decrease fatigue with or strain high temperature. In this study, time exhaustion rule ductility based on linear cumulative damage were calculated for assessments. case rule, total...