A series of new pentadentate thioether-oximes (TtoxH2, MeTtoxH2, OdtoxH2) were synthesized along with their Ni(II) and Cu(II) complexes. BF2 -bridging is accomplished by reaction of the H-bonded oxime complex with BF3·OEt2, though when Cu(BF4)2 is used as the Cu(II) salt, direct macrocyclization occurs during the metal complexation reaction. Crystallographic studies reveal: [Cu(TtoxH)]ClO4 has ...

The reactions of di-2-pyridyl ketone with Cu(O2CPh)2 in the presence of NaN3 and LiOH have led to an antiferromagnetically coupled (S = 0) Cu(II)6 cluster with a novel core and to (Cu(II)8)n and (Cu(II)2)n coordination polymers (the former 1D and the latter 2D) with interesting structures. The cluster or polymer formation depends on the reaction solvent.

Facilitated transport through polymer inclusion membranes (PIMs) is a promising method for simultaneous separation and removal of valuable and toxic metal ions from aqueous solutions. Recently, ionic liquids (ILs) have been used as extracting agents for metal ions due to their unique physicochemical properties. This paper presents research on the facilitated transport of cadmium(II) and copper(...

We validate the use of ESEEM to predict the number of (14)N nuclei coupled to a Cu(II) ion by the use of model complexes and two small peptides with well-known Cu(II) coordination. We apply this method to gain new insight into less explored aspects of Cu(II) coordination in amyloid-β (Aβ). Aβ has two coordination modes of Cu(II) at physiological pH. A controversy has existed regarding the numbe...

Ultrafast transient absorption spectra in the deep to near UV range (212-384 nm) were measured for the [Cu(II)(MeOH)(5)Cl](+) complexes in methanol following 255-nm excitation of the complex into the ligand-to-metal charge-transfer excited state. The electronically excited complex undergoes sub-200 fs radiationless decay, predominantly via back electron transfer, to the hot electronic ground st...

Two dinuclear copper(II) thioether-oxime complexes ([Cu(DtdoH)]2(ClO4)2 and [Cu(DtudH)]2(ClO4)2 Æ 2CH3OH) have been synthesized. [Cu(DtdoH)]2(ClO4)2 reacted with excess BF3 Æ OEt2 to yield [Cu(Thyclops)]ClO4, a BF2 þ-macrocyclized di-oxime. [Cu(DtdoH)]2(ClO4)2 and [Cu(DtudH)]2(ClO4)2 Æ 2CH3OH are the first representatives of copper(II) thioether oximes which exhibit the classical out-of-plane o...

This paper describes an investigation of the uptake of Cu(II) by poly(amidoamine) (PAMAM) dendrimers with an ethylenediamine (EDA) core in aqueous solutions. We use bench scale measurements of proton and metal ion binding to assess the effects of (i) metal ion-dendrimer loading, (ii) dendrimer generation/terminal group chemistry, and (iii) solution pH on the extent of binding of Cu(II) in aqueo...

New hetero-binuclear Hg-Cu Schiff base complexes were prepared by reaction of 2,2'-[1,1'-(2,2-‎dimethylpropane-1,3-diyldinitrilo)-diethyldyne]diphenolato}copper(II) (CuL1) and 6,6'-X-2,2'-[(2,2-‎dimethylpropane-1,3-diyl)bis(nitrilomethanylylidene)]diphenolato copper(II) [(X = ethoxy (CuL2) and ‎methoxy (CuL3)], with HgCl2 to give [Cu(L1)HgCl2] (1), [Cu(L2)HgCl2] (2), and [Cu(L3)HgCl2] (3), ‎res...

Site-directed mutagenesis of Pseudomonas aeruginosa azurin C112D at the M121 position has afforded a series of proteins with elevated Cu(II/I) reduction potentials relative to the Cu(II) aquo ion. The high potential and low axial hyperfine splitting (Cu(II) electron paramagnetic resonance A( parallel)) of the C112D/M121L protein are remarkably similar to features normally associated with type 1...

Survival and changes in mean body mass of whole-body irradiated mice were determined to examine the radioprotectant activity of 5-diethylsulfonamoylsalicylatocopper(II) [Cu(II) (5-DESS)]. One of four groups of 25 female C57BL/6 mice were treated subcutaneously (sc)with 0, 10, 20, 40, 60, 80, 100, or 120 mumol Cu(II)(5- DESS)/kg of body mass 3 hours before exposure to 8.0 Gy, gamma irradiation. ...