AIMS/INTRODUCTION Insulin degludec/insulin aspart (IDegAsp) is a soluble co-formulation of long-acting insulin degludec (IDeg) and rapid-acting insulin aspart (IAsp). The present study investigated the pharmacodynamic properties of IDegAsp in Japanese patients with type 1 diabetes mellitus. MATERIALS AND METHODS In this randomized, double-blind, two-period, cross-over trial, 21 Japanese patie...

BACKGROUND The assessment of RBE quantity in the treatment of cancer tumors with proton beams in treatment planning systems (TPS) is of high significance. Given the significance of the issue and the studies conducted in the literature, this quantity is fixed and is taken as equal to 1.1. OBJECTIVE The main objective of this study was to assess RBE quantity of proton beams and their variations...

Background: This study examined the pharmacokinetic profile of prednisolone. Methods: Using a newly developed ultra-performance liquid chromatography MS/MS method, prednisolone profiles in healthy volunteers and patients with adrenal insufficiency already treated with prednisolone were prospectively analyzed in a tertiary center. Results: Twelve prednisolone day curves were analyzed. Six patien...

152 drug naïve primary hypothyroid patients were divided into morning (Group 1) and evening (Group 2) dosing group and evaluated for change in biochemical profile, physical functioning and Quality of Life during the course of 12 weeks of study. At the end of 12 weeks 70 (90.90%) subjects in Group 1 and 72 (96%) in Group 2 achieved euthyroidism. On evaluation clinical symptoms and total clinical...

OBJECTIVE To compare the side effect profile of risperidone with that of oral haloperidol in patients with no previous exposure to antipsychotic drugs (APDs). BACKGROUND Early studies suggested that the APD risperidone may have a side effect profile comparable with that of placebo. These early studies involved patients with chronic schizophrenia and a long history of APD use. Very little info...

Thiazide diuretics in high dosage adversely affect the lipid profile. The non-thiazide indoline, indapamide, appears to be free of this effect, but it is unclear whether this apparent metabolic advantage of indapamide is superior to thiazides used in low dose. Since there are no large direct comparative studies to test this distinction, I surveyed the literature and pooled the findings of all p...

background: the purpose of this study was to investigate the application of the monte carlo technique to calculate and analysis of dosimetric parameters for electron beams used in radiotherapy. this technique is based on statistical method and has a powerful role in different radiotherapy aspects. materials and methods: the simulated medical linear accelerator was the varian clinac 2100c. the e...

Lisdexamfetamine dimesylate (LDX) is a long-acting d-amphetamine prodrug used to treat attention-deficit/hyperactivity disorder (ADHD) in children, adolescents and adults. LDX is hydrolysed in the blood to yield d-amphetamine, and the pharmacokinetic profile of d-amphetamine following oral administration of LDX has a lower maximum plasma concentration (Cmax), extended time to Cmax (Tmax) and lo...

Introduction: Nowadays,  considerable developments  in  the field  of  radiotherapy have  been  achieved.  They  include  the  advances  made  in  the  equipments  and  treatment  planning  techniques  which  require  highly complex calculations. Such achievements have made it possible to treat cancer patients not only  with  higher  radiation  dose  but  also  with  higher  precision  and  con...