This study was aimed to evaluate the association between preoperative high-sensitivity cardiac troponin I (hs-cTnI) level and mortality in patients undergoing liver transplantation (LT). From January 2011 to May 2016, preoperative hs-cTnI level was measured in consecutive 487 patients scheduled for LT. Patients with elevated preoperative hs-cTnI were compared with those who had normal level. Th...

BACKGROUND Increased cardiac troponin I (cTnI) in patients treated with high-dose chemotherapy (HDCT) for aggressive malignancy has been proposed as an early marker of late HDCT-induced cardiac dysfunction. We investigated whether cTnI measured by the Stratus CS (Dade Behring) would allow detection of minimal cTnI increases in patients treated with HDCT. METHODS Plasma cTnI concentrations wer...

higher) than the analytical sensitivity, allowing for acceptable clinical specificity. Furthermore, there was excellent clinical concordance between the Vitros ECi and Dade RxL cTnI assays. The cTnI values obtained with the ECi were approximately one-half of the those obtained with the RxL cTnI, probably because of the lack of antigen and antibody standardization between assays (4 ). Thus, the ...

BACKGROUND Microvascular obstruction (MVO) at the acute phase of myocardial infarction (MI) is associated with poor prognosis. We aimed to evaluate the correlation between plasma cardiac troponin I (cTnI) at the acute phase of MI and extent of no-reflow, as assessed by 3-T cardiac magnetic resonance imaging (MRI). Secondly, we defined a cut-off value for cTnI predictive of no-reflow. METHODS ...

This study compared the diagnostic accuracy of the measurement of serum cardiac troponin I (cTnI) with creatine kinase (CK) MB mass in patients with minor myocardial injury whose measured total CK activity did not exceed twice the upper reference limit (300 U/L for men; 200 U/L for women). Forty-eight consecutive patients presenting with chest pain and with in-hospital documentation of myocardi...

with CAD or MyD, cTnI was detectable in 69.2% of patients and undetectable in the remainder. In the control group (Con), cTnI was detectable in 26.2% and undetectable in 73.8% of the patients. Of the detectable values, 87.5% were 0.07 g/L (the 99th percentile value) in the CAD and MyD groups; the remainder were between 0.07 and 0.1 g/L (8.3%) or 0.1 g/L (4.2%). In the control group, all detecta...

BACKGROUND This study determines the analytical characteristics of the i-STAT cardiac troponin I assay (cTnI; i-STAT, Princeton, NJ), a 10-min POC assay, designed to be performed at the bedside. METHODS Three different hospitals participated in a patient specimen and analytical validation study (n=186) for the i-STAT cTnI assay carried out in real time. A total of 186 whole blood specimens (l...

BACKGROUND To address the continuing need for the standardization of clinical human cardiac troponin I (cTnI) assays, NIST, with the assistance of the AACC/IFCC Cardiac Troponin I Standardization Committee, has developed a new certified reference material, Standard Reference Material (SRM) 2921: Human Cardiac Troponin Complex. METHODS The concentration of cTnI in SRM 2921 was determined throu...

BACKGROUND Testing for troponin has important clinical value for patients who present with typical symptoms of acute coronary syndromes (ACS) such as chest pain (CP). Much less is known about the value of troponin testing for patients who present with other symptoms of ACS (anginal equivalent symptoms). METHODS The utilization and prognostic value of cardiac troponin I (cTnI) were evaluated a...

BACKGROUND Elevated serum cardiac troponin T (cTnT) and I (cTnI) can occur in patients with chronic kidney disease. Differences in cTn concentrations between cTnT and cTnI have been reported but the mechanism of such discrepancy has not been investigated. This study investigates the clearance of cTn with the aid of an in vitro model of haemodialysis (HD). METHODS Serum was obtained before and...