Two complexes of [Co(en)2phen] 3+ (1) and [Co(en)2bpy] 3+ (2) have been synthesized and characterized by UV/VIS, IR, H NMR spectral methods. Absorption spectroscopy, emission, viscosity measurements, DNA melting and DNA photocleavage and the binding of the two complexes with calf thymus DNA have investigated. The spectroscopic studies together with viscosity measurements and DNA melting studies...

We present a new computational strategy to evaluate the charge-transfer (CT) parameters for hole transfer in DNA. On the basis of a fragment-orbital approach, site energies and coupling integrals for a coarse-grained tight-binding description of the electronic structure of DNA are rapidly calculated using the approximative density functional method SCC-DFTB. The methodology is validated by exte...

Currently, there are approximately 80 million CT examinations [1] performed in the United States annually. This means that each patient is exposed to about 1013 photons/cm2 during the CT scan and most photon and their secondary electrons have a kinetic energy, which is higher than the ionization potential of patients DNA in cells. To date, due to the increasing number of CT examinations worldwi...

Effective wildlife management requires information on population status and distribution. Survey methods that provide estimates of these parameters can vary greatly in effort required, area covered, precision estimates, cost. Trade-offs are because increasing coverage generally field incurs a higher We compare DNA- camera trap based-spatial capture-recapture approaches (DNA-SCR CT-SCR) to the w...

Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is a rare congenital disorder of mitochondrial DNA, presenting a wide range of clinical symptoms comprising headaches, seizures, aphasia, hearing loss, visual defects, and hemiparesis. Herein we report a case of a previously asymptomatic 40-year-old male who presented with recurrent headache, seiz...

Quantum chemical studies using the accurate CASPT2//CASSCF procedure show that π-stacked interactions in biochromophores such as pyrimidine (Pyr) DNA/RNA nucleo bases pairs yield excimer-like situations which behave as precursors of processes like charge transfer (CT) or photoreactivity and are the source of the emissive properties in DNA. Examples are the CT between adjacent DNA nucleobases in...

Three isoforms of calcitonin (CT) exist in salmonids. Isohormones I and II are expressed in the pink salmon Oncorhynchus gorbuscha. We report here the existence in this species of a CT gene and of its transcripts, which encode for a fourth isohormone, the salmon CT (sCT) IV. This new CT gene was identified by PCR from genomic DNA and by sequencing the amplified DNA. The expression of this CT ge...

Adipose tissue in abdominal obesity produces various cytokines, the most important of which is adiponectin (AN). Polymorphism AN receptor genes associated with risk metabolic syndrome (MS) and type 2 diabetes mellitus (DM2) development. The aim study was to investigate association receptors’ polymorphism development MS DM2 Republic Crimea as well possibility named pathology correction polypheno...

Four organotin(IV) complexes with 2-(2-hydroxybenzylideneamino)isoindoline-1,3-dione (L(1)), and 4-(4-hydroxy-3-methoxybenzylideneamino-N-(pyrimidin-2-yl)benzenesulfonamide (L(2)) were synthesized and well characterized by analytical and spectral studies. The synthesized compounds were tested for antimicrobial activity by disc diffusion method. The DNA binding of the complexes 1 and 3 with CT-D...

In the present work, we found that methylene blue (MB) caused an efficient quenching of the fluorescence of carbon dots (CDots). However, as ct-DNA was added, the fluorescence of CDots was restored reversibly. Under the experimental conditions, CDots were excellent electron donors. MB adsorbed on the surface of CDots and quenched the fluorescence of CDots through an electron-transfer process; a...