Background: Post-neurosurgical meningitis is a significant cause of mortality and morbidity. In this study we aimed to compare the differences of clinical, laboratory features and outcomes between the post-neurosurgical meningitis caused by gram-negative bacilli (GNB) and gram-positive cocci (GPC). Methods: Cases of post-neurosurgical meningitis (with positive CSF culture) were included. After...

A 54-year-old woman presented at the hospital with headache and posterior neck pain, which worsened when standing or in sitting position improved supine position. diagnosis of rheumatoid arthritis was made age ofin 33 years, patient has been taking methotrexate methylprednisolone. Cervical MRI magnetic resonance myelography showed appearance CSF leakage, resulting a spontaneous intracranial hyp...

Adiponectin circulates in the body in high concentrations, and 100-fold lower amounts were described in the cerebrospinal fluid (CSF) of mice, whereas in humans, contradictory results have been published. To clarify whether adiponectin is present in human CSF and is derived from the circulation, it was determined in human CSF and plasma of 52 nonselected patients. Adiponectin was detected by im...

A simple and rapid detection of cerebrospinal fluid (CSF) leakage would benefit spine surgeons making critical postoperative decisions on patient care. We have assessed novel approaches to selectively determine CSF β2-transferrin (β2TF), an asialo-transferrin (aTF) biomarker, without interference from serum sialo-transferrin (sTF) in test samples. First, we performed mild periodate oxidation to...

A number of methods have evolved to examine the patient with posttraumatic CSF rhinorrhea. Until the advent of metrizamide CT cisternography, radioisotope cisternography was the predominant method of investigation. Metrizamide cisternography has preempted the use of isotopes because of its more precise ability to localize the site of CSF leakage [1-5]. However, this method, which requires lumba...

Purpose: Assessment of the efficacy of nasoseptal vascularized flap (NSF) in reconstructing the skull base defects after transsphenoidal procedures and CSF rhinorrhea. Material and Methods: Thirteen patients with intraoperative diagnosis of skull base defects and/or CSF leak after endoscopic transsphenoidal surgery or preoperative diagnosis of CSF rrhinorhea were included in this study. Multila...

A restrained 20 year old male driver presents after a rollover motor vehicle collision. He is repetitive after sustaining a loss of consciousness, but is a Glasco Coma Scale of 15 on arrival. He is complaining of left ear and shoulder pain. He has no focal findings other than a ruptured left tympanic membrane (Figure). A “halo” or “ring” sign, occurs when cerebrospinal fluid (CSF) mixes with bl...

A 32-year-old woman underwent surgeries and radiation therapy for astrocytoma. She developed symptomatic radiation necrosis in the lesion, which caused hydrocephalus. She initially underwent ventricular drainage, because the protein level in the cerebrospinal fluid (CSF) was 787 mg/dL, which was too high for shunt surgery. Because she also had breast cancer, which was pathologically diagnosed a...