We propose two ways of estimating current source density (CSD) from measurements of voltage on a Cartesian grid with missing recording points using the inverse CSD method. The simplest approach is to substitute local averages (LA) in place of missing data. A more elaborate alternative is to estimate a smaller number of CSD parameters than the actual number of recordings and to take the least-sq...

In the postgenomic era, a major challenge remains, elucidating the thermodynamic forces governing receptor-ligand specificity and promiscuity. We report a straightforward approach for mapping side-chain contributions to binding for the multipartner interactions characteristic of the human proteome. Double barrel shotgun scanning dissects binding to two or more targets through combinatorial muta...

Diagnosis of cat-scratch disease (CSD) by polymerase chain reaction (PCR) of lymph node fineneedle aspiration (FNA) and primary lesion specimens can be difficult owing to the minute amount of available material. A PCR assay specifically suited to test these specimens was developed. First, small-quantity (10 microL) samples were prepared from 17 CSD-positive and 16 CSD-negative specimens, and DN...

In this study, the performance of chirplet signal decomposition (CSD) and empirical mode decomposition (EMD) coupled with Hilbert spectrum have been evaluated and compared for ultrasonic imaging applications. Numerical and experimental results indicate that both the EMD and CSD are able to decompose sparsely distributed chirplets from noise. In case of signals consisting of multiple interfering...

Measuring and inducing neural activity in neurons using extracellular fields provides great insight into neurons functions and how they process information. This paper will consider the problem of trying to selectively sense and induce activity in neurons within a network in a living organism, using a small array of electrodes placed some distance away. One way to approach this problem is to so...

Chronic stress is associated with increased risk of cardiovascular diseases. Aging is also associated with vascular dysfunction. We hypothesize that chronic stress accelerates collateral dysfunction in old mice. Mice were subjected to either chronic social defeat (CSD) or chronic cold stress (CCS). The CSD mice were housed in a box inside an aggressor's cage and exposed to the aggressor. The CC...

Control structure design (CSD) deals with the following fundamental question: Given the process flowsheet, where should the controllers be placed, or more specifically, what variables should be measured (sensors) and manipulated (valves) and how should the two sets be interconnected for safe and economic operation? These choices are not obvious for most systems encountered in practice. The prob...

ABSTRACT Citrus sudden death (CSD), a new disease of unknown etiology that affects sweet orange grafted on Rangpur lime, was visually monitored for 14 months in 41 groves in Brazil. Ordinary runs analysis of CSD-symptomatic trees indicated a departure from randomness of symptomatic trees status among immediately adjacent trees mainly within rows. The binomial index of dispersion (D) and the int...

Conditional Sampling Distributions for Coalescent Models Incorporating Recombination by Joshua Samuel Paul Doctor of Philosophy in Computer Science and the Designated Emphasis in Computational and Genomic Biology University of California, Berkeley Professor Yun S. Song, Chair With the volume of available genomic data increasing at an exponential rate, we have unprecedented ability to address ke...

Current Source Density analysis (CSD) is a class of methods of analysis of extracellular electric potentials recorded at multiple sites leading to estimates of current sources generating the measured potentials. It is usually applied to low-frequency part of the potential (called the Local Field Potential, LFP) and to simultaneous recordings or to recordings taken with fixed time reference to t...