PURPOSE To investigate the feasibility and safety of using biocompatible, nanofibrous electrospun polycaprolactone (PCL) and combination of polylactic acid (PLLA) and PCL mats in a canine model. MATERIALS AND METHODS Plasma-treated electrospun unseeded mats were implanted in three dogs. The first dog was sacrificed after 3 months and the second and third ones after 4 months, and then, the gra...

Radiation therapy for cancer in the head and neck region leads to a marked loss of salivary gland parenchyma, resulting in a severe reduction of salivary secretions. Currently, there is no satisfactory treatment for these patients. To address this problem, we are using both tissue engineering and gene transfer principles to develop an orally implantable, artificial fluid-secreting device. In th...

Nanofibrous membranes, consisting of a poly(L-lactic acid) (PLLA)-silica xerogel hybrid material, were successfully fabricated from a hybrid sol using the electrospinning technique for guided bone regeneration (GBR) application. These hybrid nanofibers exhibited a homogeneous and continuous morphology, with a nano-sized dispersed silica xerogel phase in the PLLA fiber matrix. The mechanical pro...

Biodegradable poly(l-lactic acid) (PLLA) and PLLA/CoFe2O4 magnetic microspheres with average sizes ranging between 0.16-3.9μm and 0.8-2.2μm, respectively, were obtained by an oil-in-water emulsion method using poly(vinyl alcohol) (PVA) solution as the emulsifier agent. The separation of the microspheres in different size ranges was then performed by centrifugation and the colloidal stability as...

BACKGROUND Poly(L-lactide) (PLLA) is a biodegradable polymer currently used in many biomedical applications, including the production of resorbable surgical devices, porous scaffolds for tissue engineering, nanoparticles and microparticles for the controlled release of drugs or antigens. The surfaces of lamellar PLLA single crystals (PLLAsc) were provided with amino groups by reaction with a mu...

our previous study showed that coriandrum sativum (cs) has antinociceptive effects, but the mechanisms that mediate this effect are not clear. the present study was designed to test the role of opiate system in the antinociceptive effects of cs on acute and chronic pain in mice using hot plate (hp), tail flick (tf) and formalin (ft) tests and also to compare its effect with dexamethasone (dex) ...

Polyhroxyalkanoates (PHAs) are macromolecular storage polyesters produced by metabolic transformation of carbon sources by microorganisms, under nutrient limiting conditions. The latter involves excess of carbon source and limiting concentrations of at least one other essential nutrient, such as nitrogen, phosphorous, and/or sulphur.1 PHA accumulation as intracellular carbon and energy reserves...