The presence of multiple Nav1 isotypes within a neuron and the lack of specific blockers hamper identification of the in vivo roles of sodium current (INa) components, especially during embryonic stages. To identify the functional properties of INa components in vivo in developing neurons, we took a molecular genetic approach. Embryonic zebrafish Rohon-Beard (RB) mechanosensory neurons express ...

To analyze somatosensory neuron diversity in larval zebrafish, we identified several enhancers from the zebrafish and pufferfish genomes and used them to create five new reporter transgenes. Sequential deletions of three of these enhancers identified small sequence elements sufficient to drive expression in zebrafish trigeminal and Rohon-Beard (RB) neurons. One of these reporters, using the Fru...

By NIEL WALD, TAKASHI HOSHINO AND MARY E. SEARS MYLERAN#{176} was developed in the course of a study of the tumor-inhibiting effect of various sulfonic acid esters by Haddow and Timmis.1 Because of the neutropenia, unaccompanied by other side effects, which was observed during its ineffective clinical trial in vaniotis types of cancer in man, Myieran was employed in the treatment of chronic gra...

In this paper, microemulsion electrokinetic chromatography (MEEKC) fingerprints combined with quantification were successfully developed to monitor the holistic quality consistency of Ixeris sonchifolia (Bge.) Hance Injection (ISHI). ISHI is a Chinese traditional patent medicine used for its anti-inflammatory and hemostatic effects. The effects of five crucial experimental variables on MEEKC we...

This paper presents an empirical analysis of the relationship between fertility and poverty for Indonesia, a country which has experienced unprecedented economic growth and sharp fertility decline over recent decades. We illustrate the sensitivity of the effect of fertility on household consumption with respect to the equivalence scale in a unitary household framework. Using the propensity scor...

The crucial involvement of CLIM/NLI/Ldb cofactors for the exertion of the biological activity of LIM homeodomain transcription factors (LIM-HD) has been demonstrated. In this paper we show that CLIM cofactors are widely expressed during zebrafish development with high protein levels in specific neuronal cell types where LIM-HD proteins of the Isl class are synthesized. The overexpression of a d...

In this paper we present MAPLES (Method for Age Profiles Longitudinal EStimation), a general method for the estimation of age profiles that uses standard micro-level demographic survey data. The aim is to estimate smoothed age profiles and relative risks for time-fixed and time-varying covariates. MAPLES is implemented through a data processing routine and a series of regressions using GAM (Gen...

The operation of neuronal networks depends on the firing patterns of the network's neurons. When sustained current is injected, some neurons in the central nervous system fire a single action potential and others fire repetitively. For example, in Xenopus laevis tadpoles, primary-sensory Rohon-Beard (RB) neurons fired a single action potential in response to 300-ms rheobase current injections, ...