High BP is associated with decline of renal function. Whether this is true for very old people largely is unknown. Therefore, this study assessed the effect of BP on creatinine clearance over time in very old participants. A total of 550 inhabitants (34% men) of Leiden, The Netherlands, were enrolled in a population-based study at their 85th birthday and followed until death or age 90. BP was m...

background serum creatinine as a classic marker of renal function has several limitations in the detection of renal dysfunction. objectives this study assessed the validity of serum cystatin c as a marker of renal function in critically ill patients with normal serum creatinine. patients and methods eighty adult patients referred to intensive care units with serum creatinine levels < 1.5 mg/dl ...

OBJECTIVE: Low dose aspirin and diuretics are commonly co-utilized in patients with cardiovascular diseases. The objective of this study was to investigate the effects of low dose aspirin and diuretic drug combination on renal function. METHODS: This is a cross-sectional retrospective study. All patients, excluding those on renal dialysis, admitted to the internal department of Al-Watani hospit...

Daily urine volumes, plasma creatinine concentrations, and creatinine clearance were measured in 106 patients with unipolar and bipolar affective disorders attending a "lithium" clinic. Urine volumes exceeded 3.51 in only six patients, plasma creatinine concentrations exceeded 150 mumol/1 (1.7 mg/100 ml) in only five, and creatinine clearance was below 50 ml/min in 16. Renal function was assess...

Antonios H. Tzamaloukas, Renal Section (111C), VA Medical Center, 2100 Ridgecrest Dr, SE, Albuquerque, NM 87108 (USA) Dear Sir, Plasma concentrations of creatinine greater than 1,600 μmol/l (18 mg/dl) and urea greater than 35 mmol/l (BUN > IOO mg/dl) were proposed as indicators of inadequate peritoneal dialysis [1, 2]. However, the range of plasma concentrations of these two substances is almos...

BACKGROUND In critically ill patients with acute kidney injury, estimates of kidney function are used to modify drug dosing, adjust nutritional therapy and provide dialytic support. However, estimating glomerular filtration rate is challenging due to fluctuations in kidney function, creatinine production and fluid balance. We hypothesized that commonly used glomerular filtration rate prediction...

OBJECTIVE Various definitions of impairment of renal function after coronary artery bypass grafting (CABG) are used in the literature. Depending on the definition, several risk factors are identified. We analysed our data to determine the risk factors for postoperative deterioration of the creatinine clearance of 10% or more. METHODS All patients undergoing isolated coronary surgery in a sing...

Twenty-five years ago Rehberg proposed the exogenous creatinine clearance for the measurement of glomerular filtration rate (1). In the dog and rabbit, this clearance provides a simple and accurate method of determining the filtration rate, coinciding with the inulin and ferrocyanide clearances (2, 3). Subsequently, Shannon (4) and Miller and Winkler (5) found in man that the exogenous creatini...

Introduction: Orexins are novel neuropeptides that are localized in neurons in the lateral hypothalamus. They are implicated in a wide variety of physiological functions. Orexin peptides and receptors are found in many peripheral organs such as kidneys. It has been demonstrated that exogenous orexin-A can induce protective effects against ischemia–reperfusion injury in many organs. The goal ...

We tested two hypotheses: 1) that fibrin-containing fibrinoid-filled denudations of the syncytiotrophoblast may provide a route for paracellular diffusion and 2) that placentas from women who had elevated maternal serum alphafetoprotein (MSAFP) in midgestation had raised permeability to AFP and greater denudation than in normal pregnancy. We measured AFP and creatinine clearance across term pla...