نتایج جستجو برای: cox 1

تعداد نتایج: 2783617  

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2006
Adrian Schmassmann Georg Zoidl Brigitta M Peskar Bea Waser Diana Schmassmann-Suhijar Jan-Olaf Gebbers Jean Claude Reubi

Traditional NSAIDs, selective cyclooxygenase (COX)-2 inhibitors, and inhibitors of nitric oxide synthase (NOS) impair the healing of preexisting gastric ulcers. However, the role of COX-1 (with or without impairment of COX-2) and the interaction between COX and NOS isoforms during healing are less clear. Thus we investigated healing and regulation of COX and NOS isoforms during ulcer healing in...

امامی , سعید,

Background and purpose: Nonsteroidal anti-inflammatory drugs (NSAIDs) remain among the most widely prescribed drugs worldwide for the treatment of inflammation including pain-releasing, anti-pyretic and rheumatoid arthritis. The conventional NSAIDs exert their effects by inhibiting cyclooxygenase (COX) enzymes. Subsequent research and rational drug design validated the initial concept that a ...

ژورنال: فیض 2018

سابقه و هدف: مطالعات قبلی نقش حفاظتی آنزیم سیکلواکسیژناز را در پیشرفت صرع نشان داده ­اند. بااین­ حال، دخالت سیکلواکسیژناز-2 در بیماری­زایی صرع کاملا شناخته شده نیست. مطالعه حاضر با هدف بررسی اثر سلکوسیب و نیمزولاید (مهارکننده­ های اختصاصی سیکلو اکسیژناز-2) بر آستانه تشنج کلونیک ناشی از پنتیلن تترازول در موش­ های سوری طراحی گردید. مواد و روش ­ها: در این مطالعه تجربی موش ­های سوری نر سفید به ­صور...

Journal: :iranian journal of pharmaceutical research 0
hadi fathi-moghaddam depattment of physiology and physiology research center, school of medicine, jondishapour university of medical sciences, ahwaz, iran. mehdi shafiee ardestani department of hiv and hepatitis b and nanobiotechnology,pasteur institute of iran, tehran, iran. mostafa saffari department of pharmaceutics, faculty of pharmacy, shahid beheshti university of medical sciences, tehran, iran. ali jabbari arabzadeh depattment of physiology and physiology research center, school of medicine, jondishapour university of medical sciences, ahwaz, iran. mitra elmi department of pharmacology, razi institute for drug research, college of medicine, iran university of medical sciences, tehran, iran.

a substantial amount of evidence has proposed an important role for cyclooxygenase-2 (cox-2) enzyme in brain diseases and affiliate disorders. the purpose of this research was studying the effects of cox-2 selective inhibition on haloperidol-induced catatonia in an animal model of drug overdose and parkinson’s disease (pd). in this study, the effect of acute and sub-chronic oral administration ...

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