Targeted therapeutic approaches have seen tremendous advances in the last decade, for good reason. Specifically intervening with a disease-causing gene can revert the deleterious phenotype while eliminating the toxicity often associated with broad-spectrum agents. Unfortunately, because these selective agents hit one target in a single location, acquired resistance is often high. An arguably be...

This paper is concerned with sequential decision making by self-interested agents when their decision processes are largely independent. This situation can be formulated as a stochastic game which would traditionally be represented in extensive form (a single game tree), a representation that fails to exploit the loose coupling in the game. We propose a new representation for 2-agent loosely co...

Although jute fiber-reinforced PLA composites show strong application prospects, their low mechanical properties limit applications to some extent. In this paper, nano-SiO2 particles as well nano SiO2 modified by coupling agents which can efficiently improve the strength and toughness of composite materials are introduced into matrix. The bending, stretching thermal designed jute/PLA nonwoven w...

The objective of this study was to clarify the effects of silane coupling agents and solutions of different polarity on polymethyl methacrylate (PMMA) bonding to alumina. Three silane coupling agents (3-methacryloxypropyltrimethoxysilane (MPS),3-aminopropyltriethoxysilane (APS) and N-2 (aminoethyl) 3-aminopropyltriethoxysilane) and 3 different polar solutions, 70% ethanol, isopropanol and tolue...

In this paper we examine assets price deviation in a multi-market system with heterogeneous investors in each market. Coupled map lattices (CML) is introduced to the market maker framework. It results in market cluster sharing the same sign of deviation in the chaotic interval. Distribution plots are applied to understand the deviation persistence enhancement from the coupling e¤ect. Besides th...

Few methods address analysis of socio-technical system requirements. This paper describes a method for analysing dependencies between users/stakeholders agents and computer systems in the operational environment. Domain scenarios describing the system and its context are used to create an environment model. A method is proposed to define business organisational relationships by operationalising...

The rst part of this paper addresses Artiicial Life as an example of biologically inspired research. I discuss the general methodology and propose an interactive approach towards studying interactions and couplings of an agent within its social and non-social environment. Believ-ability and embodiment are introduced as central concepts to this approach. The second part of this paper gives four ...