Cutaneous reactions have been reported during anticoagulant therapy with coumarin derivatives, unfractionated and low molecular weight heparins, heparinoids, danaparoid and hirudins. Anticoagulant-induced skin reactions vary from local allergic manifestations to skin necrosis. In patients with allergic reactions, diagnosis and crossreactions between anticoagulants can be confirmed by intracutan...

A homogenous TR-FRET-based in vitro coupling assay for the MAP3Ks-MEK1-ERK2 kinase cascade was established and was used to screen for inhibitors of the ERK/MAPK pathway. A series of coumarin derivatives were identified from the screen. These compounds potently inhibit the activation of the unactivated human MEK1 by upstream MAP3Ks (including BRAF and COT), but do not inhibit the activity of the...

Microbial biotransformation, one of the tools of green chemistry, is widely used in organic synthesis to cutshort number of organic intermediates in obtaining the final required compounds. In the present study, an approach was made for preparing substituted derivatives of coumarin as therapeutic agents. Nine biotransformation experiments were performed where random combination of four microorga...

Capsaicin (CAP), the pungent principle from chilli peppers, has shown various activities such as analgesic, anticancer and antioxidant. To further explore a therapeutic application of this compound, several derivatives of CAP were designed and synthesized. Starting materials, CAP and dihydrocapsaicin (DHC), were obtained as a mixture from dried fruits of Capsicum annuum sp. in 0.069 % yield. St...

Abstract Selective syntheses of coumarin and benzofuran derivatives were achieved via HClO4-mediated intermolecular annulation using phenols α-methoxy-β-ketoesters. Coumarins are formed under dehydrated conditions, whereas benzofurans in the presence water. In synthetic process benzofurans, α-methoxy-β-ketoesters converted into α-methoxyacetophenones, methoxy group is an important element annul...

Three new diphenyl ether derivatives-phomaethers A-C (1-3) and five known compounds-including a diphenyl ether analog, 2,3'-dihydroxy-4-methoxy-5',6-dimethyl diphenyl ether (4); and four isocoumarin derivatives, diaportinol (5), desmethyldiaportinol (6), citreoisocoumarinol (7), and citreoisocoumarin (8)-were isolated from a gorgonian-derived fungus Phoma sp. (TA07-1). Their structures were elu...