OBJECTIVES To examine whether second-hand smoke (SHS) exposure measured by serum cotinine is associated with increased coronary heart disease (CHD) and stroke risk among contemporary older British adults. DESIGN Prospective population-based study with self-reported medical history and health behaviours. Fasting blood samples were analysed for serum cotinine and cardiovascular disease (CVD) ri...

This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. Abstract: The nicotine metabolite, cotinine (1-methyl-5-[3-pyridynl]-2-pyrrolidinone) like its precursor, has been found to exhibit pro-cognitive and neuroprotective effects in some model systems; ...

Mannino DM, Homa JM, Redd SC. Chest. 2002;122: 409–415 Purpose of the Study. To determine the indicators of asthma severity among children in the United States with high and low levels of tobacco exposure. Study Population. The subjects were 523 children (age: 4–16) with physician-diagnosed asthma. Methods. The study population was obtained from the Third National Health and Nutrition Examinati...

1 reported the interesting finding that smoking cessation in healthy males was associated with a significant increase of insulin resistance, and speculated that the increase of the body weight following smoking cessation might contribute to the worsening of insulin resistance. They dealt with a small number of subjects and the follow-up period was only 2-months. As opposite results, they cited ...

Data on risk of metabolic syndrome among various forms tobacco consumption in Myanmar users are currently limited. The present study aimed to determine and compare nicotine metabolites serum cotinine, oxidative stress marker F2-isoprostane adult male users, find out relationships between these parameters syndrome. This cross-sectional was done 30 45 years old males: 84 cigarette smokers, cheroo...

backgrand: cotinine (cot) is a major degradation product of nicotine (nic). the participation of leptin in female reproduction is well-established, but any role in male reproductive function is at the best tenuous. objective: the aim of this study was to evaluate the in-vitro effects of nicotine, cotinine and leptin on sperm parameters in normal semen of non-smokers fertile men. materials and m...

OBJECTIVE To determine quantitatively the extent of exposure of hospitality workers to environmental tobacco smoke (ETS) exposure during the course of a work shift, and to relate these results to the customer smoking policy of the workplace. SUBJECTS Three categories of non-smoking workers were recruited: (1) staff from hospitality premises (bars and restaurants) that permitted smoking by cus...

The purpose of this study was to determine the relationship between urinary cotinine and total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) concentrations in non-smoking staff and the indoor levels of fine particles (PM2.5) in hospitality venues that allow smoking, with respect to demographic and indoor environmental factors. We evaluated 62 hospitality venues that allowed smoking in Se...

BACKGROUND We have developed a device for the simplified collection of a prepurified sample of saliva in the mouth. METHOD The device is based on the principle of an osmotic pump and accumulated about 1.2 ml of an ultrafiltrate of saliva within 8 min. We have investigated the ultrafiltrate for its utility as a biological medium in the evaluation of cigarette smoking status. RESULTS (a) In 5...

BACKGROUND Cancer research is a national and international priority, with the efficiency and effectiveness of current anti-tumor therapies being one of the major challenges with which physicians are faced. OBJECTIVE To assess the impact of exposure to tobacco smoke, arsenic, and phthalates on cervical cancer treatment. METHODS We investigated 37 patients with locally advanced cervical carci...