Duchenne muscular dystrophy (DMD) is a rare pediatric-onset neuromuscular disorder. Emflaza, corticosteroid, the only therapy approved for all patients, regardless of genotype. Corticosteroids are standard care and modestly delay disease course. This study, led by Parent Project Muscular Dystrophy, uses community-engaged approach to understand corticosteroid decision making experiences. Teenage...

INTRODUCTION A meta-analysis was performed using individual patient data from the five most recent randomised controlled trials (RCTs) which evaluated corticosteroids in severe alcoholic hepatitis (Maddrey discriminant function (DF) ≥ 32 or encephalopathy). This approach overcomes limitations associated with the use of literature data and improves the relevance of the study and estimates of eff...

OBJECTIVE To identify the most common diseases and age of corticosteroid use in women over 50, dosage in last year, duration of oral corticosteroid use, prescription for fracture prevention (drug used), and referrals for bone densitometry. METHODS General practice records from 41 practices in Shropshire identified 62,230 women aged >50 from a population of 80,082. Data on fractures, duration ...

BACKGROUND Platelet-rich plasma (PRP) has shown to be a general stimulation for repair. Purpose To determine the effectiveness of PRP compared with corticosteroid injections in patients with chronic lateral epicondylitis. STUDY DESIGN Randomized controlled trial; Level of evidence, 1. PATIENTS The trial was conducted in 2 teaching hospitals in the Netherlands. One hundred patients with chro...

Background Platelet-rich plasma (PRP) has shown to be a general stimulation for repair. Purpose To determine the effectiveness of PRP compared with corticosteroid injections in patients with chronic lateral epicondylitis. Study Design Randomized controlled trial; Level of evidence, 1. Patients The trial was conducted in 2 teaching hospitals in the Netherlands. One hundred patients with chronic ...

STUDY DESIGN Prospective multi-center cohort study. OBJECTIVES This study evaluates the risk for surgical site infections (SSI) or wound healing problems (WHP) in patients who underwent corticosteroid injection prior to lumbar decompression surgery. SUMMARY OF BACKGROUND DATA Corticosteroid injections are often used for the treatment of the degenerated spine. However, their well-known immun...

BACKGROUND CONTEXT The prospective, double-blind, randomized, placebo-controlled study design is essential in the interventional spine literature to truly evaluate whether or not a procedure is effective. PURPOSE This article will critically evaluate the highest quality interventional spine literature with strict interpretation of the results of these trials. STUDY DESIGN Review article. ...

OBJECTIVES Local corticosteroid infiltration is a common practice of treatment for lateral epicondylitis. In recent studies no statistically significant or clinically relevant results in favour of corticosteroid injections were found. The injection of autologous blood has been reported to be effective for both intermediate and long-term outcomes. It is hypothesised that blood contains growth fa...

OBJECTIVE To assess whether corticosteroids, used as adjunctive therapy for pediatric severe sepsis, is associated with improved outcomes. DESIGN Retrospective cohort study examining the clinical database derived from the RESOLVE (REsearching severe Sepsis and Organ dysfunction in children: a gLobal perspective, F1K-MC-EVBP) trial of activated protein C for pediatric severe sepsis. SETTING ...

BACKGROUND AND AIMS Microarray analysis of RNA expression allows gross examination of pathways operative in inflammation. We aimed to determine whether genes expressed in whole blood early following initiation of intravenous corticosteroid treatment can be associated with response. METHODS From a prospectively accrued cohort of 128 pediatric patients hospitalized for intravenous corticosteroi...