PURPOSE To determine the prevalence of keratoconus (KCN) and subclinical KCN among subjects with two or more diopters (D) of astigmatism, and to compare Pentacam parameters among these subjects. METHODS One hundred and twenty eight eyes of 64 subjects with astigmatism ≥2D were included in the study. All subjects underwent a complete ophthalmic examination which included refraction, visual acu...

Background: The effect of corticosteroid therapy on corneal wound healing is controversial. The objective of this study was to evaluate the effects of combination therapy with dexametha-sone and acetylcysteine at different times and durations on experimentally-induced corneal wounds and haze in rabbits. Methods: Eighteen adult New Zealand white rabbits were divided into three groups of ...

PURPOSE To compare parameters of biomechanical response of the human cornea measured as corneal hysteresis (CH) and corneal resistance factor (CRF) in patients with diabetes mellitus and healthy control subjects. SETTING Department of Ophthalmology, Assaf Harofeh Medical Center, Zerifin, Israel. METHODS In the right eye of each participant, the CH, CRF, Goldmann-correlated intraocular press...

PURPOSE To investigate and map the polarizing properties of keratoconus corneas in vitro and to compare the results with those obtained in normal corneas. METHODS Corneal buttons of five keratoconus corneas were investigated by polarization-sensitive optical coherence tomography (PS-OCT). The instrument measures backscattered intensity (conventional OCT), retardation, and (cumulative) slow ax...

INTRODUCTION Laser scanning in vivo confocal microscopy (IVCM) enables non-invasive, high-resolution imaging of the cornea. In recent years, there has been a vast increase in researchers using laser scanning IVCM to image and quantify corneal nerve parameters. However, a range of methodological approaches have been adopted. The primary aim of this systematic review is to critically appraise the...

purpose : to investigate the validity of pentacam derived parameters like corneal volume distribution and percentage increase in volume in differentiation of mild to moderate keratoconus from normal corneas methods : forty eyes with mild to moderate keratoconus and 200 normal eyes were studied by pentacam. corneal volume was calculated within diameters from 1.0 to 7.0 mm with 0.5 mm steps cente...

PURPOSE We describe a novel fully automatic method capable of tracing the subbasal plexus nerves from human corneal confocal images. METHODS Following an increasing interest in the automatic analysis of corneal nerves, a few approaches have been proposed. These, however, cannot cope with large images, such as mosaics, in due time. The rationale of the proposed method is to minimize required c...

• QSPR models were developed based on in vitro corneal permeability measurements of 189 compounds. Partial least squares regression was applied for the model building. Classical molecular descriptors and ECFP fingerprints used. Corneal membrane retention values predicted by models. The capability to predict physicochemical parameters has always been a desirable objective ophthalmic drug develop...

PURPOSE To investigate the bilateral symmetry of the global corneal topography in normal corneas with a wide range of curvature, astigmatism and thickness values. DESIGN Cross-Sectional Study. METHODS Topography images were recorded for the anterior and posterior surfaces of 342 participants using a Pentacam. Elevation data were fitted to a general quadratic model that considered both trans...

PURPOSE To determine the keratometric indices calculated based on parameters obtained by Fourier-domain optical coherence tomography (FD-OCT). METHODS The ratio of anterior corneal curvature to posterior corneal curvature (Ratio) and keratometric index (N) were calculated within central 3 mm zone with the RTVue FD-OCT (RTVue, Optovue, Inc.) in 186 untreated eyes, 60 post-LASIK/PRK eyes, and 3...