نتایج جستجو برای: core promoter

تعداد نتایج: 301283  

2011
Guobao Chen Carol Shurong Tan Boon King Teh Jinhua Lu

Bachground: C1q is assembled in 1:1:1 ratio from three subunits demanding synchronized expression of three genes in a cluster – C1q deficiency causes lupus Results: A PU.1/IRF8-stimulated `core promoter’ appears to exist in this gene cluster Conclusion: A core promoter helps synchronize three C1q gene transcription Significance: This helps explain the highly conserved clustering of three C1q ge...

Journal: :The Biochemical journal 1998
G Jones M Manczak D Schelling H Turner D Jones

The binding of transcription factors to the core promoter of the juvenile hormone esterase gene was functionally characterized using both a cell-free in vitro transcription functional assay and a cell transfection assay. A core JHE promoter (-61 to +28 bp relative to transcription start site) supported faithful transcription from the in vivo transcription start site. The nuclear extracts from t...

2008
Thomas Abeel Yvan Saeys Pierre Rouzé Yves Van de Peer

MOTIVATION More and more genomes are being sequenced, and to keep up with the pace of sequencing projects, automated annotation techniques are required. One of the most challenging problems in genome annotation is the identification of the core promoter. Because the identification of the transcription initiation region is such a challenging problem, it is not yet a common practice to integrate ...

2010
Shuwen Wang Chunguang Hu Jiyue Zhu

hTERT, the human telomerase reverse transcriptase, is highly expressed in stem cells and embryonic tissues but undetectable in most adult somatic cells. To understand its repression mechanisms in somatic cells, we investigated the endogenous hTERT gene regulation during differentiation of human leukemic HL60 cells. Our study revealed that silencing of the hTERT promoter was a biphasic process. ...

Journal: :Plant physiology 2006
Kanti Kiran Suraiya A Ansari Rakesh Srivastava Niraj Lodhi Chandra Prakash Chaturvedi Samir V Sawant Rakesh Tuli

A prototype 13-bp TATA-box sequence, TCACTATATATAG, was mutated at each nucleotide position and examined for its function in the core promoter. Specific nucleotides in the first TATA, the second TATA, as well as the flanking sequences influenced promoter function in transient transformation of tobacco (Nicotiana tabacum var Petit Havana) leaves. The effect of a given mutation on reporter gene e...

Journal: :Cardiovascular research 2004
Ping Yang Sabina Kupershmidt Dan M Roden

OBJECTIVE Despite the primacy of the sodium current in cardiac electrophysiology and evidence that decreased sodium current is arrhythmogenic in humans, little is known about transcriptional regulation of the underlying gene, SCN5A. METHODS We have cloned a 2.7 kb segment of 5'-flanking region of SCN5A and identified multiple transcription initiation sites by primer extension and RNase protec...

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