During ATP hydrolysis the K+-translocating Kdp-ATPase from Escherichia coli forms a phosphorylated intermediate as part of the catalytic cycle. The influence of effectors (K+, Na+, Mg2+, ATP, ADP) and inhibitors (vanadate, N-ethylmaleimide, bafilomycin A1) on the phosphointermediate level and on the ATPase activity was analyzed in purified wild-type enzyme (apparent Km = 10 microM) and a KdpA m...

A critical first step in a "rational vaccine design" approach for hepatitis C virus (HCV) is to identify the most relevant mechanisms of immune protection. Emerging evidence provides support for a protective role of virus neutralizing antibodies, and the ability of the B cell response to modify the course of acute HCV infection. This has been made possible by the development of in vitro cell cu...

Hepatitis C virus (HCV) is a major cause of liver disease worldwide and there is a pressing need for the development of a preventative vaccine as well as new treatments. It was recently demonstrated that the mouse monoclonal antibody (mAb) AP33 potently neutralizes infectivity of HCV pseudoparticles (HCVpp) carrying E1E2 envelopes representative of all of the major genotypes of HCV. This study ...

Introduction: The restoration material commonly used as core material for pulpless posterior teeth is mostly amalgam due to its high strength and low cost and it can be used with or without pin. The aim of this study was to evaluate the influence of post material on stress distribution in mandibular second premolar tooth by finite element analysis. Method: The stress distribution was analyzed i...

Objective- We assessed the effect of change in core isometric strength and endurance on upper limb isometric strength in female athletes. Methods- In this experimental study, 32 female athletes aged 18-25 years were recruited based on the inclusion criteria. (17 cases in the experimental group and 15 cases in the control group). Before and after the core stabilization knockdown protocol, parti...

objective: the aim of this study was to compare the microtensile bond strengths (μ tbs) of three core materials with one lithium disilicate reinforced ceramic using two resin cements. methods: three core materials (nulite f® (biodental technologies), filtek z250® (3m-espe), prettau-anterior® (zirkonzhan, germany)) were prepared as blocks (10×10×4 mm3) according to the manufacturer’s instruction...