Background Methods for haplotyping and DNA copynumber typing of single cells are paramount for studying genomic heterogeneity and enabling genetic diagnosis. Before analyzing the DNA of a single cell by microarray or next-generation sequencing, a whole-genome amplification (WGA) process is required, but it substantially distorts the frequency and composition of the cell’s alleles. As a conseque...

In keyboard writing, typing skills are considered an important prerequisite of proficient text production. We describe the design, implementation, and application a standardized copy-typing task in order to measure assess individual fluency. A test-retest analysis indicates instrument’s reliability. While has been developed across eleven different languages related layouts, we here refer corpus...

We have studied cardiovascular and renal phenotypes in Npr1 (genetic determinant of natriuretic peptide receptor-A; NPRA) gene-disrupted mutant mouse model. The baseline systolic arterial pressure (SAP) in 0-copy mutant (-/-) mice (143 +/- 2 mmHg) was significantly higher than in 2-copy wild-type (+/+) animals (104 +/- 2 mmHg); however, the SAP in 1-copy heterozygotes (+/-) was at an intermedia...

Cancer is a disease of the genome and the epigenome. Previous studies have shown that genomic changes such as mutations, copy number variation, and genomic rearrangements drive cancer evolution. In this issue of Cancer Cell, Landau and colleagues add epigenomic changes, specifically locally disordered DNA methylation, to cancer's evolutionary trajectory.

ibn far?gh?n’s djaw?mi‘ al-‘ul?m hooshang a‘lam ibn far?gh?n’s djaw?mi‘ al-‘ul?m hooshang a‘lam this is an unpublished work by the late dr. hooshang a‘lam on ibn far?gh?n’s djaw?mi‘ al-‘ul?m. the work has been written in french and translated into persian by mrs. negar naderi. the scan copy of dr. a’lam’s handwriting is provided at the end of the article. this is an unpublished work by the late...