OBJECTIVE To determine the contribution of 7,8-methylenedioxylycoctonine (MDL)-type alkaloids to the toxic effects of tall larkspur (Delphinium spp) consumption in cattle. ANIMALS Sixteen 2-year-old Angus steers. PROCEDURES Plant material from 3 populations of tall larkspur that contained different concentration ratios of MDL-type-to-N-(methylsuccinimido) anthranoyllycoctonine (MSAL)-type a...

Toxicosis was induced in pregnant Holstein heifers by feeding FireMaster BP-6 (polybrominated biphenyls) in daily oral doses of 25 g/head/day for 33--60 days. The individual heifers were dosed until each became moribund (days 33, 36, 39, 40, 41, or 66), at which time they were necropsied. Gross findings included dehydration, subcutaneous emphysema and hemorrhage, atrophy of the thymus, fetal de...

OVER THE PAST DECADE, COMMD1 (copper metabolism MURR1 domain containing protein 1) has been regularly identified to interact with ion transport proteins. What do we know about COMMD1, and is there a common ion transport regulatory role for COMMD1? COMMD1 is evolutionarily conserved, and codes for a 21-kDa protein composed of two domains: a COOH-terminal COMM domain found in nine other COMMD pro...

To evaluate treatments purportedly beneficial for livestock grazing locoweeds (LW), growing rats were fed diets containing 10 or 20% whole-plant Oxytropis sericea (LW) with and without Silent Herder mineral mix (1.5% of diet) or bentonite clay (1.5% of diet). Pregnant female rats fed 10% LW were treated i.m. with Banamine (a prostaglandins suppressor) or saline. The LW contained swainsonine (43...

Abstract Quercetin is a natural flavonoid with higher antioxidant capacity and anti-inflammatory. Tall fescue [Schedonorus arundinaceus (Schreb.) Dumort; E+] perennial cool-season grass for grazing livestock in North America. Fescue infected the endophyte (Neotyphodium coenophialum) produces chemicals toxic to livestock. However, impact of quercetin on alleviating toxicosis has received only li...