Background: Oral topiramate is a broad-spectrum antiepileptic drug. There is limited documented data on its use in refractory convulsive and non-convulsive status epilepticus. Methods: A retrospective study of the clinical characteristics and responses of patients diagnosed as status epilepticus treated with topiramate at the Srinagarind Hospital, Khon Kaen University from 2001-2010. Results: T...

The purpose of this article is to describe the clinical and electroencephalographic features of patients diagnosed with non-convulsive status epilepticus (NCSE) with uncommon cognitive and behavioral involvement. We present two cases with sub-acute cognitive impairment and neuropsychiatric disorders (including anxiety and transient behavioral changes) as their first manifestation of NCSE. A neu...

Acta Neurologica Taiwanica Vol 19 No 2 June 2010 From the Department of Neurology, Taipei Veterans General Hospital, Taipei Taiwan. Received May 31, 2010. Revised and Accepted May 31, 2010. Reprint requests and correspondence to: Shang-Yeong Kwan, MD. Department of Neurology, Taipei Veterans General Hospital, 16F, No. 201, Section 2, Shipai Rd., Taipei Taiwan. E-mail: [email protected] The R...

Historically, demonic possession and act of spirits were suspected to explain the strange symptoms of epilepsy. Even nowadays, not all symptoms of epilepsy are clear. Some epileptic semiology's are very bizarre reflecting the little we know about human brain. Focal non motor seizures are subjective experiences. Frontal hyper motor seizures can be wrongly diagnosed as agitations. Absence attacks...

Abbreviations: VGKC: Voltage-gated Potassium Channel; NMDAR: N-methyl, D-aspartate Receptor; LGI 1: Leucin-Rich Glioma-Inactivated-1; CASPR 2: Contact in-Associated Protein-2; SE: Status Epilepticus; WBC: White Blood Count; ALT: Alanine Transaminases; AST: Aspartate Transaminases; HSV-1: Herpes Simplex Virus; PCR : Polymerase Chain Reaction; EEG: Electro Encephalogram; CT: Computed Tomography; ...

INTRODUCTION Convulsive status epilepticus is a common emergency condition in paediatric practice. Classically, it is defi ned as continuous or recurrent seizure activity lasting for longer than 30 min in which the patient does not regain baseline mental status.1 Commonly, intervention is recommended after only 5 min of seizure activity2 as neuronal damage may begin to occur after this period, ...

Therapeutic hypothermia (TH) has rarely been utilized as an adjunct to anticonvulsants in treating patients with refractory convulsive status epilepticus (CSE). However, determining the effectiveness of TH in CSE is difficult due to the unavoidable use of sedative drugs to manage hypothermia. Additionally, the effectiveness of TH has not been studied in patients with refractory non-convulsive s...

We report a case of lithium overdose in a patient who presented in non-convulsive status epilepticus. The lithium toxicity was probably due to interaction with Moduretic. The diagnosis was not suspected until electroencephalography was performed. This case underscores the importance of therapeutic drug level monitoring of lithium, especially where toxicity is suspected, and the indispensable ro...