We administered cis-diamminedichloroplatinum(II), 30 mg/m2/day for 5 days by continuous infusion to six patients with head and neck cancer, and compared the total and filterable plasma concentrations of platinum, and toxic effects, with those observed in five additional patients who received the same dose and schedule of cis-diamminedichloroplatinum(II) by intermittent bolus. In the continuous ...

BACKGROUND We have developed an analogue of postflight sensorimotor dysfunction in astronauts using pseudorandom galvanic vestibular stimulation (GVS). To date there has been no study of the effects of extended GVS on human subjects and our aim was to determine optimal exposure for astronaut training based on tolerance to intermittent and continuous galvanic stimulation. METHODS There were 60...

A continuous flow methodology is described which gives α-alkylated ketones in good yields, avoids cryogenic temperatures, excessive exposure to alkyllithiums/alkylhalides, and can be easily continuously scaled-out (to >3 g 45 min).

Maternal low protein diet programs offspring to develop hypertension as adults. Transient exposure to angiotensin converting enzyme inhibitors or angiotensin II receptor blockers can result in improvement in hypertension. Male rats whose mothers received a low protein diet during the last half of pregnancy were given either vehicle, continuous enalapril (CE) in their drinking water or were give...

Food allergy is most frequently the result of IgE-mediated hypersensitivity reactions. Here, we describe a chronic model in which some of the intestinal and systemic consequences of continuous egg white solution ingestion by ovalbumin-sensitized eight-week-old BALB/c mice, 6 animals per group, of both sexes, were investigated. There was a 20% loss of body weight that began one week after antige...

Chronic early gestational chorioamnionitis is associated with development of bronchopulmonary dysplasia in preterm infants. A single intra-amniotic exposure to endotoxin decreased alveolarization and reduced expression of endothelial proteins in 125-day gestational age preterm lambs. We hypothesized that prolonged exposure to intra-amniotic endotoxin would cause progressive lung inflammation an...

Misclassification into exposure categories formed from a continuous variable arises from measurement error in the continuous variable. Examples and mathematical results are presented to show that if the measurement error is nondifferential (independent of disease status), the resulting misclassification will often be differential, even in cohort studies. The degree and direction of differential...

Repeat Use of Post-Exposure Prophylaxis for HIV among Nairobi-Based Female Sex Workers Following Sexual Exposure Single-Tablet Emtricitabine-Rilpivirine-Tenofovir as HIV Post-Exposure Prophylaxis in Men Who Have Sex with Men Missed Opportunities along the Prevention of Mother-to-Child Transmission Services Cascade in South Africa: Uptake, Determinants, and Attributable Risk (the SAPMTCTE) Impro...

The effects of multiple mating on Þtness in the rice weevil, Sitophilus oryzae L. (Coleoptera: Curculionidae), were studied. In the Þrst of a series of experiments, the impact of multiple mating on female Þtness was determined by evaluating the effects of a single mating period with one male, continuous exposure to one male, and continuous exposure to Þve males. Continuous exposure to one male ...