The United States generates nearly 325 billion gallons of wastes and by-products during the processing of foods. Whey is a by-product produced in cheese industry and it is estimated that as much as 40-50% of the whey produced is disposed of as sewage or applied to agricultural lands. The remaining 50-60% is being used primarily for animal feed or for human food. Whey contains high quantity of l...

Much effort has been devoted to develop and advance the methodology to regenerate functional small-diameter arterial bypasses. In the physiological environment, both mechanical and chemical stimulation are required to maintain the proper development and functionality of arterial vessels. Bioreactor culture systems developed by our group are designed to support vessel regeneration within a preci...

Steady state and dynamic fermentations of baker's yeast in molasses based media were analyzed in a laboratory scale bioreactor. Sugar and biomass balances together with the Monod biokinetics were used to develop the process model. Parameters of the model were obtained using collected experimental data. Model predicted open loop responses to step changes in feed concentration as well as dilu...

steady state and dynamic fermentations of baker's yeast in molasses based media were analyzed in a laboratory scale bioreactor. sugar and biomass balances together with the monod biokinetics were used to develop the process model. parameters of the model were obtained using collected experimental data. model predicted open loop responses to step changes in feed concentration as well as dilution...

the performance of a forced-liquid vertical tubular loop bioreactor (vtlb), a forced-liquid horizontal tubular loop bioreactor (htlb) and a gas-induced external airlift loop bioreactor (ealb) were compared for production of biomass from natural gas. hydrodynamic characteristics and mass transfer coefficients were determined as functions of design parameters, physical properties of gases as well...

Performance efficiency in a Downflow Hanging Sponge (DHS) bioreactor is associated with the amount of time that a wastewater remains in the bioreactor. The bioreactor is considered as a plug flow reactor and its hydraulic residence time (HRT) depends on the void volume of packing material and the flow rate. In this study, hydraulic behavior of DHS bioreactor was investigated by using tracer met...

Mercury-contaminated chemical wastewater of a mercury cell chloralkali plant was cleaned on site by a technical-scale bioremediation system. Microbial mercury reduction of soluble Hg(II) to precipitating Hg(0) decreased the mercury load of the wastewater during its flow through the bioremediation system by up to 99%. The system consisted of a packed-bed bioreactor, where most of the wastewater'...

Recent advances in mammalian, insect, and stem cell cultivation and scale-up have created tremendous opportunities for new therapeutics and personalized medicine innovations. However, translating these advances into therapeutic applications will require in vitro systems that allow for robust, flexible, and cost effective bioreactor systems. There are several bioreactor systems currently utilize...

The skin is susceptible to different injuries and diseases. One major obstacle in skin tissue engineering is how to develop functional three-dimensional (3D) substitute for damaged skin. Previous studies have proved a 3D dynamic simulated microgravity (SMG) culture system as a "stimulatory" environment for the proliferation and differentiation of stem cells. Here, we employed the NASA-approved ...

The removal of trace organic compounds (TrOCs) by a novel membrane distillation-thermophilic bioreactor (MDBR) system was examined. Salinity build-up and the thermophilic conditions to some extent adversely impacted the performance of the bioreactor, particularly the removal of total nitrogen and recalcitrant TrOCs. While most TrOCs were well removed by the thermophilic bioreactor, compounds co...