PURPOSE To examine cell proliferation of the normal corneal epithelium and during extended rigid gas-permeable (RGP) lens wear. METHODS Twenty-three New Zealand White rabbits were fitted unilaterally with either a low oxygen transmissible (Dk/t) or hyper-Dk/t RGP lens, with the other eye serving as a control. The rabbits were injected with 5-bromo-2-deoxyuridine (BrdU) 24-hours later and kill...

PURPOSE The aim of this study was to quantify specific proteins deposited on daily wear silicone hydrogel lenses used in combination with multipurpose disinfecting solutions (MPDSs) by applying multiple-reaction-monitoring mass spectrometry (MRM-MS). METHODS Balafilcon A or senofilcon A contact lenses used with different MPDSs on a daily wear schedule were collected. Each worn lens was extrac...

Albumin surface deposits were significantly higher on contact lenses from subjects with CLPC (p<0.0001, Figure 5). m Lenses from six of the CLPC subjects were analysed prior to the event. There was no difference in the amount of HSA on these lenses compared to the CLPC lenses. m Lactoferrin amounts were not significantly different between the CLPC and non-CLPC groups (Figure 6). m The amount of...

Nocardia farcinica is one of the more recently identified species of the Nocardia genus. Nocardia farcinica keratitis is a rare occurrence, with only eight previously reported cases. Semi-permeable rigid contact lens use was associated with one of these reported cases. We report the first case of an extended wear soft contact lens-related Nocardia farcinica keratitis and recommend a new treatme...

BACKGROUND Most corneal damage induced by contact lenses is due to interference with corneal oxygenation. OBJECTIVE To investigate the effect on the rabbit cornea of a rigid gas-permeable contact lens with a newly designed periphery. METHOD We fitted New Zealand white rabbits (n = 12) with RGP contact lenses that were identical in all respects except for the design of the periphery. In each...

PURPOSE To evaluate the effect of soft contact lens type on the in vivo tear film surface quality (TFSQ) on daily disposable lenses and to establish whether two recently developed techniques for noninvasive measurement of TFSQ can distinguish between different contact lens types. METHODS Thirteen subjects wearing four different types of daily soft contact lenses participated in the study. Dyn...

acanthamoeba keratitis is a vision-threatening infection caused by pathogenic species of the genus acanthamoeba. in this study, 13 acanthamoeba keratitis cases were diagnosed among 52 keratitis patients. to confirm the identity of acanthamoeba at the genus level, a pcr-based method was used, and their pathogenic potential was determined using in vitro cytotoxicity assays on human corneal epithe...

purpose : acanthamoeba keratitis (ak) is a sight-threatening corneal infection with a rapidly increased incidence since 1990s along with the growing popularity of contact lenses. in this study we aimed to study patients with ak and its associated risk factors in farabi eye hospital of tehran, focusing on those with more severe corneal involvement. methods : patients with clinical or laboratory ...

purpose: to compare rose-k and conventional rgp contact lenses in terms of visual acuity, visual function and comfort in keratoconus patients. method: fifty-four patients with keratoconus were randomly fitted with rose-k and conventional rgp contact lens (wohlk contact lens), by one experienced ophthalmologist using a standard (three touch point) approach. general and demographic information, k...