We present a layered graph model for delay-constrained minimum tree problems with a polynomial number of constraints which can be solved well for instances with lowto medium-sized sets of achievable delay values and not too high bounds. Layered graph models have been recently shown to frequently yield tight bounds in the context of hopor delay-constrained network design problems. However, since...

In genomic analysis, there is growing interest in network structures that represent biochemistry interactions. Graph structured or constrained inference takes advantage of a known relational structure among variables to introduce smoothness and reduce complexity in modeling, especially for high-dimensional genomic data. There has been a lot of interest in its application in model regularization...

Identifying and protecting the trusted computing base (TCB) of a system is an important task, which is typically performed by designing and enforcing a system security policy and verifying whether an existing policy satisfies security objectives. To efficiently support these, an intuitive and cognitive policy analysis mechanism is desired for policy designers or security administrators due to t...

background in this article, we analyze one case instance of how proposals for change to the priority setting and resource allocation (psra) processes at a canadian healthcare institution reached the decision agenda of the organization’s senior leadership. we adopt key concepts from an established policy studies framework – kingdon’s multiple streams theory – to inform our analysis.   methods tw...

an inoculation of virulent leishmania major is known as leishmanization (lz) which is proven to be the most effective control measure against cutaneous leishmaniasis (cl). however, using lz is restricted due to various side effects such as uncontrolled lesion development. in the present research, the efficacy of cationic nanoliposomes containing cpg oligodeoxynucleotides (cpg odn) as an improve...

Non-parallel text style transfer has attracted increasing research interests in recent years. Despite successes transferring the based on encoder-decoder framework, current approaches still lack ability to preserve content and even logic of original sentences, mainly due large unconstrained model space or too simplified assumptions latent embedding space. Since language itself is an intelligent...

This paper is concerned with the saddle-path stability of monetary growth rules in a two-country two-sector dynamic stochastic general equilibrium model. Alongside standard features of emerging economies, such as a combination of producer and local currency pricing for exports, fiscal dominance and oil exports, this model also incorporates informal labour and production sectors and examines how...

Background: Dendritic cells (DCs) are professional antigen presenting cells that have an important role in the initiation of immune response. The use of maturation factors in dendritic cell differentiation provides a promising approach in immunotherapy. Objective: In this study, we compared tumor necrosis factor-α, polyribocytidylic acid, lipopolysacharide and CpG oligonucleotides in inducing d...