نتایج جستجو برای: connecting rod
تعداد نتایج: 53293 فیلتر نتایج به سال:
Mutations in the extracellular matrix protein eyes shut homolog (EYS) cause photoreceptor degeneration in patients with retinitis pigmentosa 25 (RP25). Functions of EYS remain poorly understood, due in part to the lack of an EYS gene in mouse. We investigated the localization of vertebrate EYS proteins and engineered loss-of-function alleles in zebrafish. Immunostaining indicated that EYS local...
Heterotrimeric kinesin-II is a molecular motor localized to the inner segment, connecting cilium and axoneme of mammalian photoreceptors. Our purpose was to identify the role of kinesin-II in anterograde intraflagellar transport by photoreceptor-specific deletions of kinesin family member 3A (KIF3A), its obligatory motor subunit. In cones lacking KIF3A, membrane proteins involved in phototransd...
An elemental SMA actuator, consisting of an elastic rod with two embedded SMA wires, is presented. The recovering wire w1, with remembered ‘U’ shape, is located along the rod’s axis. The restoring wire w2, with memorized straight shape, is located in parallel with the rod’ axis with an offset distance d1. Two strain gauges, arranged in complemental configuration and sticking to the rod, are use...
The energy minimization problem associated to uniform, isotropic, linearly elastic rods leads to a geometric variational problem for the rod centerline, whose solutions include closed, knotted curves. We give a complete description of the space of closed and quasiperiodic solutions. The quasiperiodic curves are parametrized by a two-dimensional disc. The closed curves arise as a countable colle...
Transplantation of rod photoreceptors, derived either from neonatal retinae or pluripotent stem cells (PSCs), can restore rod-mediated visual function in murine models of inherited blindness. However, humans depend more upon cone photoreceptors that are required for daylight, color, and high-acuity vision. Indeed, macular retinopathies involving loss of cones are leading causes of blindness. An...
Talin is an adaptor protein that couples integrins to F-actin. Structural studies show that the N-terminal talin head contains an atypical FERM domain, whereas the N- and C-terminal parts of the talin rod include a series of α-helical bundles. However, determining the structure of the central part of the rod has proved problematic. Residues 1359-1659 are homologous to the MESDc1 gene product, a...
The rod portion of the rod cell in the frog's retina is divided into two parts; namely inner and outer segments. The latter is mainly occupied by the pile of so called rod-sacs which are arranged perpendicularly to the long axis of the rod (1-3). The inner segment is connected with the outer segment by a short slender stalk (or connecting cilium) (4, 5), which has a columnar shape and extends f...
Opsin molecules on the surface of frog photoreceptors were visualized by immunocytochemistry at the ultrastructural level. Isolated retinas were immersed in biotinyl-antibody to bovine opsin followed by avidin-ferritin conjugates. Anti-opsin bound to the plasma membrane and to the surface of the most basal discs of red rod outer segments. Inner segment plasma membranes of red rod photoreceptors...
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