OBJECTIVE Leptin administration is known to directly modulate pancreatic β-cell function in leptin-deficient rodent models. However, human studies examining the effects of leptin administration on β-cell function are lacking. In this study, we examined the effects (16-20 weeks) of leptin replacement on β-cell function in patients with lipodystrophy. RESEARCH DESIGN AND METHODS In a prospective,...

Parton distributions play an important role in the QCD description of hard scattering processes. In particular, generalized parton distributions (GPDs) and transverse momentum dependent parton distributions (TMDs) have extensively been studied during the last decade. We focus here on the most general form of quark-quark correlation functions, the socalled generalized transverse momentum depende...

The Generalized Estimating Equations (GEE) proposed by Liang and Zeger (1986) have found considerable attention in the last years and several extensions have been proposed. This paper will give a more intuitive description how GEE have been developed during the last years. Additionally we will describe the advantages and disadvantages of the diierent parametrisations that have been proposed in ...

Congenital generalized lipodystrophy (CGL) with severe hypertriglyceridemia in a children less than 1 year of age is associated with worse metabolic risk. We used data from patient records, as well as extensive literature research to write the manuscript. We report the case of an infant with typical phenotype of CGL and hypertriglyceridemia of 1,360 mg/dL who was treated with bezafibrate at a d...

BACKGROUND Berardinelli-Seip congenital lipodystrophy (BSCL) was initially described by Berardinelli in Brazil in 1954 and 5 years later by Seip in Norway. It is an autosomal recessive disease that leads to a generalized deficit of body fat, evolving with diabetes and hypertriglyceridemia. The aim of this study was to describe the clinical and laboratory characteristics of a large series of pat...

Generalized hyperbolic Lévy motions constitute a broad subclass of Lévy processes which are generated by generalized hyperbolic (GH) distributions. GH distributions were introduced in [1] in connection with a project with geologists. The Lebesgue density of this 5-parameter class can be given in the following form dGH(λ,α,β,δ,μ)(x) = a(λ, α, β, δ, μ)(δ + (x− μ)2)(λ− 1 2 )/2 × Kλ− 2 (α √ δ2 + (x...