abstract Discordant alternans, the phenomenon of separate cardiac tissue locations exhibiting action potential duration (APD) alternans of opposite phase, appears to be a potential mechanism for electrocardiographic T wave alternans, but its initiation mechanism is unknown. We studied behavior of one-and two-dimensional cardiac tissue spatially homogeneous in all respects, including APD restitu...

Obese individuals have slowed conduction in the median nerve across the wrist, but the mechanism for this is not established. This case-control study of 27 obese subjects and 16 thin subjects was designed to test the hypothesis that obese individuals have higher carpal canal pressures and more median nerve swelling than thin individuals. All subjects were asymptomatic for hand symptoms, and had...

Multielectrode recordings have revealed zero time lag synchronization among remote cerebral cortical areas. However, the axonal conduction delays among such distant regions can amount to several tens of milliseconds. It is still unclear which mechanism is giving rise to isochronous discharge of widely distributed neurons, despite such latencies. Here, we investigate the synchronization properti...

We report telemetry recording of an extreme non-fatal tachyarrhythmia noted in a hospitalized quadriplegic male with history of atrial fibrillation where the average ventricular conduction rate was found to be about 600 beats per minute and was associated with transient syncope. A medical literature review suggests that the fastest human ventricular conduction rate reported to date in a tachyar...

The crystallographic structure of a potassium channel, Kv1.2, in an open state makes it feasible to simulate entire K(+) ion permeation events driven by a voltage bias and, thereby, elucidate the mechanism underlying ion conduction and selectivity of this type of channel. This Letter demonstrates that molecular dynamics simulations can provide movies of the overall conduction of K(+) ions throu...

We clarify the nature of the dimerized ground state found in the one-dimensional Kondo lattice model at quarter conduction electron filling. The conduction electrons mediate, through the RKKY mechanism, the long-range interactions among localized spins necessary to induce dimerization in that sub-system. On the other hand, the feedback of the local moments on the conduction electron fluid does ...

In a patient with Wolff-Parkinson-White syndrome whose accessory pathway was primarily capable of bidirectional conduction, antegrade conduction over the accessory pathway was transiently inhibited after rapid atrial or ventricular pacing or after spontaneous termination of atrioventricular reentrant tachycardia. Pacing rate and duration of tachycardia were related to the duration of the suppre...

Two cases of acute ophthalmoplegia, ataxia, and arreflexia with high CSF protein are reported (Miller Fisher syndrome). Detailed EMG and nerve conduction studies showed abnormal conduction in peripheral sensory fibres from the initial stages of the illness in both patients. Careful review up to 10 months after the onset was required to document the sensory conduction abnormality properly in one...

BACKGROUND #ENTITYSTARTX02014; Sometime, it's difficult to distinguish the electrophysiological mechanism of some tachycardia, and so, influencing the efficacy and safety of ablation operation. Therefore, it's helpful to analysis some tachycardia in particular mechanism, as in this case. METHODS AND RESULTS #ENTITYSTARTX02014; A 49 years old Chinese male patient had a history of paroxysmal pa...