本稿では，統合失調症患者に併存する強迫症状に関する疫学，臨床的特徴，治療について概説する。一般人口に比べ，統合失調症患者における強迫症状の有病率は高い。統合失調症患者に強迫症状が存在することは，予後を悪くし，患者の情動と心理社会的機能に悪影響を与える。強迫症状を伴う統合失調症患者において，強迫症状について病識を欠く患者はわずか15.8％であり，純粋な強迫症患者中の病識を欠く患者の割合と類似している。治療には，薬物療法と曝露反応妨害法を用いた認知行動療法がある。第二世代抗精神病薬の使用によって強迫症状が誘発されている場合，薬物療法としては，原因となっている抗精神病薬の減薬や他の抗精神病薬への変更，アリピプラゾールの付加がある。抗精神病薬誘発性の場合も含め，統合失調症患者に併存する強迫症状についても，SSRIの投与は有益である。

The current study examined scrupulosity in 352 unselected college students as measured by the 19-item Penn Inventory of Scrupulosity (PIOS). Confirmatory factor analysis yielded support for a two-factor model of the 19-item PIOS. However, item-level analyses provided preliminary support for the validity of a 15-item PIOS (PIOS-R) secondary to the removal of items 2, 6, 15, and 10. The two domai...

Obsessive-compulsive (OC) symptoms during the course of schizophrenia have been reported, yet the incidence and significance of this finding is still unclear. This study was undertaken to determine the prevalence of OC symptoms among chronic schizophrenic patients and to systematically identify them. 101 patients satisfying DSM-IV diagnosis of chronic schizophrenia were assessed for OC symptoms...

OBJECTIVE This study investigated the prevalence and phenomenology of body dysmorphic disorder in patients with obsessive-compulsive disorder. METHOD The authors studied 442 patients who participated in the DSM-IV field trial for obsessive-compulsive disorder. RESULTS Twelve percent (N = 51) of the patients had a lifetime comorbid diagnosis of body dysmorphic disorder. Patients with and wit...

The present case report describes an intensive treatment approach combining aggressive pharmacotherapy with daily cognitive behavioral therapy (CBT) directed at helping “Dee,” a 63-year-old female suffering from compulsive hoarding. The successful intervention consisted of individualized exposure and response prevention (ERP), in addition to cognitive restructuring to improve insight, decrease ...