Failure of compliance with drug treatment is a major problem in all diseases requiring long-term therapy. The incidence of noncompliance is variously reported as between 5% and 60% in well-conducted investigations in hypertensive patients. Direct (objective) methods give a higher incidence of noncompliance than indirect (subjective) methods. Among factors associated with noncompliance, the comp...

This study compared the efficiency and safety of definitive concurrent chemoradiotherapy (CCRT) using Paclitaxel plus Cisplatin (TP) versus S-1 plus Cisplatin (CS) in unresectable locally advanced esophageal squamous cell carcinoma (LAESCC). Between January 2009 and December 2013, 203 LAESCC patients were retrospectively reviewed. We performed a propensity score matching analysis; 41 patients t...

OBJECTIVE We investigated the pathological effects of neoadjuvant chemotherapy based on the human epidermal growth factor receptor 2 in operable breast cancer. METHODS This prospective clinical study was a pilot involving 63 female patients. Before surgery, patients with tumors overexpressing human epidermal growth factor receptor 2 received four cycles of 60 mg/m(2) anthracycline and 600 mg/...

Over the past 20 years there has been increasing interest in the menopause and hormone replacement therapy (HRT). More recently, postmenopausal HRT has been seen as a specific treatment for symptoms in the short term and preventative therapy in the long term. Women must be counselled regarding the risks and benefits of HRT according to the best available evidence. The patient should also be act...

CONTINUOUS POSITIVE AIRWAY PRESSURE (CPAP) HAS BEEN DEMONSTRATED AS AN EFFECTIVE TREATMENT FOR PATIENTS WITH OBSTRUCTIVE SLEEP APNEA (OSA).1 However, poor compliance with CPAP has been identified as a significant obstacle in the successful treatment of OSA.2-7 The degree of compliance with CPAP is a significant factor in determining improvement in daytime sleepiness and other health-related out...

conclusions among the treatment regimens containing dcv, dcv/sof has the highest svr rate for the treatment of infection with different hcv genotypes in different patient contexts; thus, this regimen shows promise for the treatment of hcv infections. results we found six different regimens containing dcv: dcv/asunaprevir (asv), dcv/asv/beclubavir, dcv/pegylated interferon lambda or alpha/rbv wi...

The present study was conducted to examine the role of health locus of control and compliance to medical regimen in controlling and managing diabetes. Participants of the study were 200 diagnosed diabetic patients (Females=100, Males=100), out of which 100 had controlled diabetes and 100 had uncontrolled diabetes. Health Locus of control was measured by Wallston’s HLC scale and Compliance behav...

Hydrogels Kristy M. Wood and Nicholas A. Peppas The main advantage of oral protein delivery is that it improves patient compliance and comfort over other routes of administration (i.e. injection), thus leading to a more effective treatment regimen. Although oral protein delivery could benefit many individuals, maintaining the functionality of the protein and low bioavailability of the delivered...