CD8+ T cells are thought to play an important role in protective immunity to tuberculosis. The major histocompatibility complex class I subtype HLA-A*0201 is one of the most prevalent class I alleles, with a frequency of over 30% in most populations. HLA-A*0201 transgenic, H-2Db/mouse beta2-microglobulin double-knockout mice (HHD) which express human HLA-A*0201 but no mouse class I, was shown t...

Light-harvesting complex I (LHCI), which serves as a peripheral antenna for photosystem I (PSI) in green plants, consists mainly of four polypeptides, Lhca1-4. We report room temperature emission properties of individual reconstituted monomeric Lhca proteins (Lhca1, -2, -3, and -4) and dimeric Lhca1/4, performed by steady-state and time-resolved fluorescence techniques. The emission quantum yie...

Infinite dimensional complex analysis was a popular subject in the sixties and seventies, but in the last fifteen years enjoyed much less attention. Oddly enough, this very same period began to see the emergence of examples of infinite dimensional complex manifolds, in mathematical physics, representation theory, and geometry. Thus it appears to be a worthwhile undertaking to revisit infinite d...

The world is increasingly moving towards a complex web of systems. The reductionist scientific paradigm of studying closely one part at a time is not sufficient enough to understand structural and functional features of these systems. The field of complex systems focuses on interactions and functions between parts that lead to the emergence of new order and coherence which is only evident in th...

Mitochondrial disorders (MIDs) present with a broad range of clinical manifestations [1] and often with large intra-and interfamilial pheno-typic heterogeneity [2], which is why it is often difficult to suspect an MID. In single cases or at onset of the disease, manifestations may be mild and non-specific [3], as in the following case. The patient is a 56-year-old Caucasian male, with a history...

Recent evidence highlights that the cancer cell energy requirements vary greatly from normal cells and that cancer cells exhibit different metabolic phenotypes with variable participation of both glycolysis and oxidative phosphorylation. NADH-ubiquinone oxidoreductase (Complex I) is the largest complex of the mitochondrial electron transport chain and contributes about 40% of the proton motive ...

We discuss Chapter 6 from Silverman & Tate’s Rational Points on Elliptic Curves, in which the authors outline a means of proving Kronecker’s Jugendtraum for Q and Q(i). One considers C[n], the kernel of the multiplication-by-n map on an elliptic curve C. After defining the number field Q(C[n]), we examine instances in which its Galois group over a field K is abelian. For the elliptic curve

AnH-function with complex parameters is defined by aMellin-Barnes type integral. Necessary and sufficient conditions under which the integral defining the H-function converges absolutely are established. Some properties, special cases, and an application to integral transforms are given. 2000 Mathematics Subject Classification. Primary 33C60.

Complex I is the only component of the eukaryotic respiratory chain of which no high-resolution structure is yet available. A notable feature of mitochondrial complex I is the so-called active/de-active conformational transition of the idle enzyme from the active (A) to the de-active, (D) form. Using an amine- and sulfhydryl-reactive crosslinker of 6.8Å length (SPDP) we found that in the D-form...

We present 12CO,13CO and C18O J=1→0, and 12CO and 13CO 2→1 and 3→2 observations of the Rosette Molecular Complex (RMC), obtained with the KOSMA 3m and IRAM 30m telescopes. We introduce a method for correcting error beam pick-up of single-dish telescopes in spectral line radio maps by using observations of a smaller telescope and apply it to correct the IRAM 30m data presented in this paper by t...