Introduction Conclusions References

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We present here by direct argument the classical Clopper-Pearson (1934) “exact” confidence bounds and corresponding intervals for the parameter p of the binomial distribution. The same arguments can be applied to derive confidence bounds and intervals for the negative binomial parameter p, for the Poisson parameter λ, for the ratio of two Poisson parameters, ρ = λ1/λ2, and for the parameter D o...

Set-point theory posits that individuals react to the experience of major life events, but quickly adapt back to pre-event baseline levels of subjective well-being in the years following the event. A large, nationally representative panel study of Swiss households was used to examine set-point theory by investigating the extent of adaptation following the experience of marriage, childbirth, wid...

Context. Brown dwarf companions to stars at separations of a few AU or less are rare objects, and none have been found so far around early-type M dwarfs (M0V-M5V). With GJ 1046 (M2.5V), a strong candidate for such a system with a separation of 0.42 AU is presented. Aims. We aim at constraining the mass of the companion in order to decide whether it is a brown dwarf or a low-mass star. Methods. ...

Companion diagnostics are used to aid clinical decision making to identify patients who are most likely to respond to treatment. They are becoming increasingly important as more new pharmaceuticals receive licensed indications that require the use of a companion diagnostic to identify the appropriate patient subgroup for treatment. These pharmaceuticals have proven benefit in the treatment of s...

THIS short book is one of a series of three volumes summarizing the principles of obstetrics, gynaecology and neonatal medicine. It is essentially a book of lists written by two doctors: "a medical adviser to a major pharmaceutical company," and "a physiological laboratory worker" respectively. The authors and their colleagues are said to have conceived this book during their 'shop-floor' exper...

Using extensive HST imaging, combined with Chandra X-ray and Parkes radio data, we have detected the optical binary companion to a second millisecond pulsar (MSP) in the globular cluster 47 Tucanae. This faint (V = 22.3) blue (V − I = 0.7) star shows a large amplitude (60–70%) sinusoidal variation in both V and I. The period (3.19066 hr) and phase of the variation match those of the MSP 47 Tuc ...

Human history reveals that the way in which humans treat animals is based on their views of themselves as well as of the living environment around them. These views may vary from an assumption of human superiority to one of equality between humans and animals. Recent trends affecting companion-animal welfare are: modern philosophies on animal issues, the specialised and varied roles that compan...

It has been proposed that cortical neurons organize dynamically into functional groups (cell assemblies) by the temporal structure of their joint spiking activity. Here, we describe a novel method to detect conspicuous patterns of coincident joint spike activity among simultaneously recorded single neurons. The statistical significance of these unitary events of coincident joint spike activity ...