buthotus schach is one of the dangers scorpion in iran that belong to the buthidae family. toxins are existing in venom scorpion, modulate the ion channels by blocking or opening the pore of the channel or by altering the voltage gating and useful as pharmacological tools. in the present study, we investigated the effect of venom and its obtained fractions by gel filtrations on electrophysiolog...

nowadays people are seeking health information to raise their awareness. they use many ways to get this information. this study examines the health information channels used by users of public libraries. the population of the present survey  consisted of 461 users of public libraries throughout the country, randomly selected in a two-stage cluster sampling method. the questionnaire data were an...

lymphangioma circumscriptum is a benign lymphatic malformation which is localized to the skin and subcutaneous tissues. it consists of dilated lymph channels lined by normal endothelium.primary vulvar involvement is very rare and only 28 cases have been reported till 2002. here we report a case in an 18 years old girl who was referred to our gynecologic clinic with symptoms of pain,swelling and...

major proportion of intracellular calcium (ca 2+ ) is achieved through opening of calcium channels present in the plasma membrane which play an important role in regulating neuromuscular coordination and release of neurotransmitters from nerve terminals. blockade of these calcium channels adversely affect contractile process and release of neurotransmitters in majority of the neuromuscular prep...

concentrations of eight metals namely, cr, mn, fe, co, ni, cu, zn and pb were examined in the surface sediments of discharge channels of six industries in lagos using x-ray fluorescence spectrometry.these channels drain into the isolo canal which empties into the lagos lagoon and eventually into the atlantic ocean. this study was conducted to detect any contamination levels within the sediment...

Background: K+ channel toxins are essential tools for the first purifications, analysis of subunit structures and brain localization of voltage-gated K+ (Kv) channels. The effects of a lot of toxins on Kv are not fully known. Methods: Using whole-cell patch clamping technique the action of a series of toxins on Kv3.4 current in rat liver cells with expressed Kv3.4 channels (RLE) cloned cells wa...

ATP-sensitive potassium (KATP) channel openers have a relaxation effect due to the lower cellular membrane potential and inhibit calcium influx. There has been considerable interest in exploring KATP channel openers in the treatment of various diseases such as cardiovascular, cerebrovascular, and urinary system disease and premature labor. The purpose of this study was to synthesize 3,3,6,6-tet...

This article evaluates the effect of membrane active channel-forming polyene antibiotic (PA) of levorin and its alkyl derivatives on the muscle performance. The membrane channels of muscle cells are capable to transport ions of potassium, sodium, and calcium. In the period of an intensive muscle exercise, the necessity for organic substrates increases and these channels start to work with the g...