a compact formulation of the set of tours neither in a graph nor its complement is presented and illustrates a general methodology proposed for constructing polyhedral models of decision problems based upon permutations, projection and lifting techniques. directed hamilton tours on n vertex graphs are interpreted as (n-1)- permutations. sets of extrema of birkhoff polyhedra are mapped to tours ...

Solid phase peptide synthesis method, which was introduced by Merrifield in 1963, has spawned the concept of combinatorial chemistry. In this review, we summarize the present technologies of solid phase peptide synthesis (SPPS) that are related to combinatorial chemistry. The conventional methods of peptide library synthesis on polymer support are parallel synthesis, split and mix synthesis and...

To design diverse combinatorial libraries or to select diverse compounds to augment a screening collection, computational chemists frequently reject compounds that are > or =0.85 similar to one already chosen for the combinatorial library or in the screening set. Using Daylight fingerprints, this report shows that for IC(50) values determined as a follow-up to 115 high-throughput screening assa...