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New cervical cancer prevention strategies are arising from rapidly improving insight into human papillomavirus (HPV) natural history and cervical carcinogenesis, challenging the conventional roles of cytology and colposcopically directed biopsy as the reference standards of screening and diagnosis, respectively. HPV testing has high sensitivity but mediocre specificity and positive predictive v...

OBJECTIVE It has been suggested that the accuracy of colposcopy is less reliable than once presumed. The Reid colposcopic index is the most well-known scoring system designed to standardize colposcopic assessment and assist in the prediction of histological diagnosis. Strander et al. have devised a new scoring system, the Swede score, which includes lesion size as a variable. This evaluation ai...

OBJECTIVE Referral for colposcopy because of abnormal Pap test results is likely to be distressing, but the extent and duration of these effects are unknown. We aimed to fill this gap. METHODS We conducted a prospective observational study at two departments of Obstetrics and Gynecology (an academic and a non-academic setting). Women referred for colposcopy completed questionnaires before col...

OBJECTIVES Evaluation of the performance of VIA (visual inspection with acetic acid) trained nurses to learn colposcopy and the Swede score method to detect cervical lesions by using stationary colposcope or a portable, hand-held colposcope; the Gynocular, as compared to doctors. DESIGN A crossover randomised clinical trial. SETTING The Colposcopy Clinic of Bangabandhu Sheikh Mujib Medical ...

Cervical intraepithelial neoplasia 3 (CIN3) is the precursor of mostsquamous carcinomas and serves as a surrogate end point. However, small CIN3 lesions are rarely associated with concurrent invasion. We hypothesized that aggressive follow-up for cytology of atypical squamous cells of undetermined significance (ASCUS) or low-grade squamous intraepithelial lesion (LSIL) leads predominantly to de...

OBJECTIVES The aim of this study was to estimate the time and travel costs generated by women when attending for Papanicolaou (Pap) smear tests or colposcopy appointments in the United Kingdom, both absolutely and relative to the health service cost of the national cervical cancer screening programs. METHODS Data were obtained from questionnaires completed by two samples of women participatin...

Background Colposcopy is recommended once human papillomavirus (HPV)16/18 infection detected. However, not all HPV16/18-positive women will necessarily develop cervical lesions. Therefore, this study aimed to investigate the application of quantitative HPV16 E7 oncoprotein detection as a cancer screening method for more efficient while minimizing unnecessary colposcopy. Methods (HPV16) was quan...

OBJECTIVE To determine if electrical impedance spectroscopy (EIS) improves the diagnostic accuracy of colposcopy when used as an adjunct. DESIGN Prospective, comparative, multi-centre clinical study. SETTING Three colposcopy clinics: two in England and one in Ireland. POPULATION Women referred with abnormal cytology. METHODS In phase 1, EIS was assessed against colposcopic impression an...