نتایج جستجو برای: colorectal tumor
تعداد نتایج: 494611 فیلتر نتایج به سال:
Background & Aims: Colorectal cancer is the third most common cancer in Iran. Wnt pathway changes are commonly reported in this type of cancer. Some of the important activities of this pathway are the role of carcinogenicity, cellular proliferation, cell migration, and so on. Axin2 acts as a negative regulator in the Wnt / TCF signaling pathway and helps in the formation of the beta-catenin des...
OBJECTIVE In colorectal carcinomas, tumor budding has been defined as the presence of isolated single tumor cells or small cell clusters in the stroma at the invasive tumor margin. In this study, the relationship between tumor budding density at the invasive tumor margin and pathological parameters is investigated. MATERIAL AND METHOD Haematoxylin and eosin stained slides of 73 cases with col...
BACKGROUND & AIMS There are few validated biomarkers that can be used to predict outcomes for patients with colorectal cancer. Part of the challenge is the genetic and molecular heterogeneity of colorectal tumors not only among patients, but also within tumors. We have explored intratumor heterogeneity at the epigenetic level, due to its dynamic nature. We analyzed DNA methylation profiles of t...
Metastasis-associated protein family (MTA) promotes tumor cell invasion and metastasis of human malignancies. However, the novel component of MTA family, MTA3 was found to play conflicting roles in human malignancies. While the expression pattern and potential function of MTA3 in colorectal cancer has not been addressed yet. In the present study, we investigated the protein expression of MTA3 b...
BACKGROUND Thymidine phosphorylase (TP) is a key enzyme involved in pyrimidine nucleoside metabolism. Dihydropyrimidine dehydrogenase (DPD) is the major catabolic enzyme of 5-fluorouracil (5-FU). These are important enzymes in the pyrimidine salvage pathway and are considered to be key enzymes for determining the prognosis of patients with gastrointestinal cancer. In the present study, TP and D...
UNLABELLED Epidemiological studies prove that incidence of colorectal cancer is increasing. The first line therapy of colorectal cancer is surgical resection of the primary tumor and elimination of regional and remote metastases. THE AIM OF THE STUDY was to determine expression of adhesion molecules CD134 and CD137 in the peripheral blood in colorectal cancer patients, depending on clinical can...
PURPOSE Both CD44 and CD133 were reported as putative markers for isolating colorectal cancer stem cells (CSC). It remains to be resolved if both of these markers are of functional importance for colorectal CSC. EXPERIMENTAL DESIGN The expression of CD44 and CD133 in normal colonic tissues and primary colorectal cancer was assessed by immunohistochemistry in a series of 60 patients on tissue ...
The aim of antitumor immunotherapy is to induce CTL responses against autologous tumors. Previous work has shown that fusion of human dendritic cells and autologous tumor cells induce CTL responses against autologous tumor cells in vitro. However, in the clinical setting of patients with colorectal carcinoma, a major difficulty is the preparation of sufficient amounts of autologous tumor cells....
Background and purpose: Colorectal cancer (CRC) is the third most common cancer in men and fourth in women. In Iran, its prevalence rate is currently growing. Many risk factors are believed to be associated with this disease, but in recent years, the role of chemokines especially CXCR4 is outstanding. This study aimed at investigating the relationship between clinicopathological characteristics...
Background ; Objectives: Identifying the important influential factors is a great challenge in oncology studies. Decision tree is one of methods that could be used to evaluate the prognostic factors and classifying the patients' homogeneously. This method identifies the main prognostic factors and then determines the subgroups of patients based on those prognostic factors. The aim of this...
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