Development of colonic diverticulosis is a function of age and declining colonic wall mechanical strength. The latter is partly a consequence of changes in the collagen structure. Collagen from unaffected human colons (n = 20, age range 20-80 years) and those with colonic diverticulosis (n = 5, age range 67-80 years) were obtained at necropsy. The total collagen content was measured as the hydr...

This study aimed to investigate the protective potential of genistein in dextran sulfate sodium (DSS)-induced colonic injury in vitro and in vivo models. The results showed that DSS exposure caused growth suppression, colonic injury, inflammation, and barrier dysfunction in mice. Dietary genistein alleviated DSS-caused colonic injury via reducing colonic weight, rectal bleeding, and diarrhea ra...

Electroacupuncture (EA) has been shown to improve impaired gastric motility and slow waves in both humans and animals. However, its effects on colonic motility have rarely been investigated. The aim of this study was to investigate the effects and underlying mechanisms of EA on impaired colonic motility induced by rectal distension (RD)in dogs. Colon contractions and transit were measured in va...

PURPOSE To evaluate a canine intestinal accessport model to study colonic absorption of drugs. The antiepileptic drugs phenytoin and gabapentin were chosen to study absorption of a lipophilic and hydrophilic compound, respectively. METHODS Drug plasma level-time plots were generated subsequent to small intestinal and colonic drug administration of both drugs. The poorly water-soluble phenytoi...

Colonic epithelial stem cells are believed to be located at the crypt base where they have previously been shown to express musashi-1. The colonic stem cell niche, which includes extracellular matrix and myofibroblasts (together with other cell types), is likely to be important in maintaining the function of the progenitor cells. The aims of our studies were to characterize stem cells in isolat...

We investigated the mechanisms of dysmotility of the colonic circular muscle of the Crohn’s disease model rat. Contractions induced by KCl, carbachol, and Bay K 8644 were decreased in circular smooth muscles isolated from TNBS-induced colitis rat colon. However, the absolute force and Ca sensitivity of contractile proteins were not affected as assessed in α-toxin permeabilized smooth muscle. Th...

To cite: Simons A, Finnerty J, Meara N, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/ bcr-2014-208013 DESCRIPTION An 80-year-old man was referred to the lung cancer clinic with a CT scan showing irregularity in the trachea and larger airways (figure 1). He had a history of prostate cancer, rheumatoid arthritis, colonic polyps and diverticulosis. He had no co...

BACKGROUND Due to the extremely rare incidence, data about colonic GISTs are limited. Therefore, aim of the present study was to explore clinicopathological characteristics and prognosis of colonic GISTs. PATIENTS AND METHODS Colonic GISTs cases were obtained from our center and from case report and clinical studies extracted from MEDLINE. Clinicopathological features and survivals were analy...